| Novo Holdings A/S | 3,686,622 | $64,756 |
| FCPM III SERVICES B.V. | 3,226,400 | $56,672 |
| T. Rowe Price Investment Management, Inc. | 2,799,180 | $49 |
| GOLDMAN SACHS GROUP INC | 1,937,168 | $34,026 |
| BlackRock, Inc. | 1,095,514 | $19,243 |
| Nan Fung Group Holdings Ltd | 971,253 | $17,060 |
| 5AM Venture Management, LLC | 950,011 | $16,687 |
| Sanofi | 912,041 | $16,020 |
| VANGUARD GROUP INC | 869,668 | $15,276 |
| Pivotal bioVenture Partners Investment Advisor LLC | 611,447 | $10,743 |
| PERCEPTIVE ADVISORS LLC | 550,000 | $9,661 |
| Velan Capital Investment Management LP | 522,305 | $9,174 |
| Siren, L.L.C. | 450,000 | $7,904 |
| GEODE CAPITAL MANAGEMENT, LLC | 389,026 | $6,835 |
| Vestal Point Capital, LP | 385,000 | $6,763 |
| BAKER BROS. ADVISORS LP | 364,705 | $6,406 |
| Jain Global LLC | 327,693 | $5,756 |
| Blue Owl Capital Holdings LP | 327,058 | $5,745 |
| STATE STREET CORP | 229,484 | $4,031 |
| LAZARD ASSET MANAGEMENT LLC | 207,494 | $3,645 |
| Board of Trustees of The Leland Stanford Junior University | 199,233 | $3,500 |
| CITADEL ADVISORS LLC | 190,139 | $3,340 |
| Freestone Grove Partners LP | 183,771 | $3,228 |
| Tetragon Partners GP Ltd | 164,525 | $2,890 |
| BNP Paribas Investment Partners S.A. | 147,930 | $3 |
| DAFNA Capital Management LLC | 143,764 | $2,525 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,427 | $2,431 |
| NORTHERN TRUST CORP | 119,557 | $2,100 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $1,757 |
| STEMPOINT CAPITAL LP | 100,000 | $1,757 |
| Burkehill Global Management, LP | 75,000 | $1,317 |
| AMERIPRISE FINANCIAL INC | 66,872 | $1,175 |
| DIADEMA PARTNERS LP | 63,791 | $1,120 |
| ORBIMED ADVISORS LLC | 56,000 | $952 |
| TUDOR INVESTMENT CORP ET AL | 47,840 | $840 |
| MARSHALL WACE, LLP | 39,659 | $697 |
| BANK OF AMERICA CORP /DE/ | 37,820 | $664 |
| TD Asset Management Inc | 36,960 | $649 |
| Bank of New York Mellon Corp | 35,857 | $630 |
| BARCLAYS PLC | 26,415 | $464 |
| MORGAN STANLEY | 23,222 | $408 |
| Persistent Asset Partners Ltd | 21,766 | $382 |
| Nuveen, LLC | 20,197 | $355 |
| Ghisallo Capital Management LLC | 20,000 | $351 |
| WELLS FARGO & COMPANY/MN | 18,687 | $328 |
| UBS Group AG | 18,290 | $321 |
| OXFORD ASSET MANAGEMENT LLP | 17,763 | $312 |
| MILLENNIUM MANAGEMENT LLC | 13,945 | $245 |
| RHUMBLINE ADVISERS | 13,642 | $240 |
| Lynx1 Capital Management LP | 13,477 | $237 |
| Invesco Ltd. | 12,970 | $228 |
| DEUTSCHE BANK AG\ | 11,928 | $210 |
| Walleye Capital LLC | 11,686 | $205 |
| LMR Partners LLP | 10,000 | $176 |
| MetLife Investment Management, LLC | 9,798 | $172 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,815 | $137 |
| JPMORGAN CHASE & CO | 6,743 | $118 |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,300 | $93 |
| Police & Firemen's Retirement System of New Jersey | 3,986 | $70 |
| BNP PARIBAS ARBITRAGE, SA | 3,455 | $61 |
| STRS OHIO | 3,000 | $53 |
| Tower Research Capital LLC (TRC) | 2,870 | $50 |
| Legal & General Group Plc | 1,649 | $29 |
| Ameritas Investment Partners, Inc. | 1,371 | $24 |
| Russell Investments Group, Ltd. | 1,337 | $23 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,040 | $18 |
| FMR LLC | 904 | $16 |
| SBI Securities Co., Ltd. | 607 | $11 |
| ROYAL BANK OF CANADA | 582 | $10 |
| AMALGAMATED BANK | 530 | $0 |
| Sterling Capital Management LLC | 519 | $9 |
| Federation des caisses Desjardins du Quebec | 500 | $9 |
| CITIGROUP INC | 383 | $7 |
| Farther Finance Advisors, LLC | 120 | $2 |