MAST THERAPEUTICS INC

CUSIP: 576314108 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 1,374,900 Value ($000) $667 Avg Close — Range —
Q4 2014
Shares 1,374,900 Value ($000) $770 Avg Close — Range —