MEDICINES CO

CUSIP: 584688105 Class: COM

RTW INVESTMENTS, LP's Holding History (CIK: 0001493215)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 572,689 Value ($000) $28,004 Avg Close — Range —
Q4 2016
Shares 374,263 Value ($000) $12,702 Avg Close — Range —
Q3 2016
Shares 123,000 Value ($000) $4,642 Avg Close — Range —