MEDICINES CO

CUSIP: 584688105 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 60,000 Value ($000) $2,240 Avg Close — Range —
Q2 2015
Shares 180,000 Value ($000) $5,150 Avg Close — Range —
Q1 2015
Shares 100,000 Value ($000) $2,802 Avg Close — Range —
Q4 2014
Shares 100,000 Value ($000) $2,767 Avg Close — Range —
Q4 2013
Shares 44,000 Value ($000) $1,699 Avg Close — Range —