MINERALYS THERAPEUTICS INC

Ticker: MLYS CUSIP: 603170101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 610,403 Value ($000) $22,152 Avg Close $40.10 Range $33.63 - $47.65

Q1 2025

Shares 48,532 Value ($000) $771 Avg Close $11.50 Range $8.24 - $18.38

Q2 2024

Shares 16,134 Value ($000) $189 Avg Close $12.59 Range $10.37 - $15.00

Q1 2024

Shares 15,624 Value ($000) $202 Avg Close $12.35 Range $7.95 - $16.91

Q4 2023

Shares 64,723 Value ($000) $557 Avg Close $7.85 Range $5.85 - $10.09

Q3 2023

Shares 36,103 Value ($000) $343 Avg Close $13.04 Range $8.87 - $17.05

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	610,403	$22,152	$40.10	$33.63 - $47.65
Q1 2025	48,532	$771	$11.50	$8.24 - $18.38
Q2 2024	16,134	$189	$12.59	$10.37 - $15.00
Q1 2024	15,624	$202	$12.35	$7.95 - $16.91
Q4 2023	64,723	$557	$7.85	$5.85 - $10.09
Q3 2023	36,103	$343	$13.04	$8.87 - $17.05