| Catalys Pacific, LLC | 7,903,838 | $286,830 |
| RA CAPITAL MANAGEMENT, L.P. | 7,323,750 | $265,779 |
| Samsara BioCapital, LLC | 5,871,018 | $213,059 |
| FMR LLC | 5,057,509 | $183,537 |
| BlackRock, Inc. | 4,327,678 | $157,051 |
| VANGUARD GROUP INC | 3,352,880 | $121,676 |
| STATE STREET CORP | 3,184,999 | $115,584 |
| Caligan Partners LP | 2,772,654 | $100,620 |
| FRANKLIN RESOURCES INC | 1,788,747 | $64,914 |
| Laurion Capital Management LP | 1,713,485 | $62,182 |
| Holocene Advisors, LP | 1,602,035 | $58,138 |
| Andera Partners | 1,591,917 | $57,771 |
| SR ONE CAPITAL MANAGEMENT, LP | 1,563,966 | $56,756 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,538,662 | $55,838 |
| GOLDMAN SACHS GROUP INC | 1,450,933 | $52,654 |
| Polar Capital Holdings Plc | 1,401,141 | $50,847 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,325,120 | $48 |
| SAMLYN CAPITAL, LLC | 1,304,932 | $47,356 |
| JENNISON ASSOCIATES LLC | 1,258,653 | $45,677 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,582 | $45,645 |
| JANUS HENDERSON GROUP PLC | 1,213,265 | $44,005 |
| Point72 Asset Management, L.P. | 1,207,220 | $43,810 |
| Capital International Investors | 1,163,290 | $42,216 |
| D. E. Shaw & Co., Inc. | 1,150,670 | $41,758 |
| BOOTHBAY FUND MANAGEMENT, LLC | 992,082 | $36,003 |
| BANK OF AMERICA CORP /DE/ | 987,280 | $35,828 |
| ORBIMED ADVISORS LLC | 980,400 | $35,579 |
| ALLIANCEBERNSTEIN L.P. | 922,516 | $33,478 |
| AMERICAN CENTURY COMPANIES INC | 908,093 | $32,955 |
| Pictet Asset Management Holding SA | 852,883 | $30,951 |
| FARALLON CAPITAL MANAGEMENT LLC | 823,296 | $29,877 |
| WELLINGTON MANAGEMENT GROUP LLP | 784,267 | $28,461 |
| Integral Health Asset Management, LLC | 750,000 | $27,218 |
| Affinity Asset Advisors, LLC | 730,000 | $26,492 |
| Siren, L.L.C. | 699,999 | $25,403 |
| Candriam S.C.A. | 678,387 | $24,620 |
| ARMISTICE CAPITAL, LLC | 676,035 | $24,533 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 659,076 | $23,918 |
| MORGAN STANLEY | 639,507 | $23,208 |
| TWO SIGMA INVESTMENTS, LP | 610,403 | $22,152 |
| Qube Research & Technologies Ltd | 496,549 | $18,020 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,300 | $16,741 |
| SPHERA FUNDS MANAGEMENT LTD. | 449,003 | $16,294 |
| Rock Springs Capital Management LP | 427,596 | $15,517 |
| Parkman Healthcare Partners LLC | 410,249 | $14,888 |
| CITADEL ADVISORS LLC | 399,919 | $14,513 |
| TimesSquare Capital Management, LLC | 380,100 | $13,794 |
| 22NW, LP | 358,325 | $13,004 |
| TWO SIGMA ADVISERS, LP | 353,700 | $12,836 |
| Catalio Capital Management, LP | 331,849 | $12,043 |
| RENAISSANCE TECHNOLOGIES LLC | 322,100 | $11,689 |
| LORD, ABBETT & CO. LLC | 312,396 | $11 |
| NORTHERN TRUST CORP | 299,863 | $10,882 |
| STEMPOINT CAPITAL LP | 290,049 | $10,526 |
| Iron Triangle Partners LP | 257,085 | $9,330 |
| MARSHALL WACE, LLP | 249,130 | $9,041 |
| Squarepoint Ops LLC | 246,804 | $8,957 |
| SG Americas Securities, LLC | 230,795 | $8 |
| BARCLAYS PLC | 223,283 | $8,103 |
| Swedbank AB | 221,400 | $8,035 |
| Davern Capital Partners, LP | 210,648 | $7,644 |
| UBS Group AG | 201,280 | $7,304 |
| Ikarian Capital, LLC | 200,000 | $7,258 |
| Russell Investments Group, Ltd. | 175,361 | $6,364 |
| Buckley Capital Advisors, LLC | 174,300 | $6,325 |
| BNP PARIBAS ARBITRAGE, SA | 172,929 | $6,276 |
| Velan Capital Investment Management LP | 151,000 | $5,480 |
| Burkehill Global Management, LP | 150,000 | $5,444 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,208 | $5,197 |
| Rhenman & Partners Asset Management AB | 142,571 | $5,174 |
| Brevan Howard Capital Management LP | 139,293 | $4,984 |
| Artia Global Partners LP | 137,800 | $5,001 |
| DIMENSIONAL FUND ADVISORS LP | 137,636 | $4,993 |
| ADAR1 Capital Management, LLC | 136,231 | $4,944 |
| Bank of New York Mellon Corp | 131,839 | $4,784 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 130,592 | $4,636 |
| Rafferty Asset Management, LLC | 127,917 | $4,642 |
| HighVista Strategies LLC | 124,544 | $4,520 |
| Nuveen, LLC | 122,947 | $4,462 |
| Simplify Asset Management Inc. | 114,182 | $4,144 |
| Nantahala Capital Management, LLC | 113,285 | $4,111 |
| Trexquant Investment LP | 112,788 | $4,093 |
| Voya Investment Management LLC | 112,672 | $4,089 |
| Ensign Peak Advisors, Inc | 112,190 | $4,071 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 111,753 | $4,056 |
| EAM Investors, LLC | 96,135 | $3,489 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 94,983 | $3,447 |
| Swiss National Bank | 90,100 | $3,270 |
| PRUDENTIAL FINANCIAL INC | 89,065 | $3,232 |
| Verition Fund Management LLC | 83,840 | $3,043 |
| MILLENNIUM MANAGEMENT LLC | 78,625 | $2,853 |
| Susquehanna Portfolio Strategies, LLC | 78,092 | $2,834 |
| UBS ASSET MANAGEMENT AMERICAS INC | 75,897 | $2,754 |
| XTX Topco Ltd | 73,678 | $2,674 |
| Hennion & Walsh Asset Management, Inc. | 69,362 | $2,517 |
| Greenland Capital Management LP | 69,000 | $2,504 |
| Blue Owl Capital Holdings LP | 65,944 | $2,393 |
| ALPS ADVISORS INC | 64,987 | $2,358 |
| WINTON GROUP Ltd | 64,806 | $2,352 |
| AQR CAPITAL MANAGEMENT LLC | 62,300 | $2,261 |
| 122 other institutions | 1,874,633 | $64,096 |