MONOPAR THERAPEUTICS INC

Ticker: MNPR CUSIP: 61023L207 Class: Common Stock

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 639,467 Value ($000) $41,757 Avg Close $81.71 Range $63.73 - $105.00

Q3 2025

Shares 659,195 Value ($000) $53,836 Avg Close $44.70 Range $29.18 - $81.89

Q2 2025

Shares 599,195 Value ($000) $21,439 Avg Close $36.32 Range $26.05 - $46.60

Q1 2025

Shares 599,195 Value ($000) $21,817 Avg Close $36.03 Range $21.00 - $54.30

Q4 2024

Shares 599,195 Value ($000) $13,182 Avg Close $16.78 Range $4.50 - $38.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	639,467	$41,757	$81.71	$63.73 - $105.00
Q3 2025	659,195	$53,836	$44.70	$29.18 - $81.89
Q2 2025	599,195	$21,439	$36.32	$26.05 - $46.60
Q1 2025	599,195	$21,817	$36.03	$21.00 - $54.30
Q4 2024	599,195	$13,182	$16.78	$4.50 - $38.50