| JANUS HENDERSON GROUP PLC | 1,317,410 | $85,908 |
| RA CAPITAL MANAGEMENT, L.P. | 667,207 | $43,569 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 639,467 | $41,757 |
| Saturn V Capital Management LP | 325,701 | $21,268 |
| VANGUARD GROUP INC | 293,816 | $19,186 |
| BlackRock, Inc. | 254,857 | $16,642 |
| ADAR1 Capital Management, LLC | 233,908 | $15,274 |
| WELLINGTON MANAGEMENT GROUP LLP | 226,068 | $14,762 |
| Siren, L.L.C. | 212,298 | $13,863 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 170,558 | $11,137 |
| TCG Crossover Management, LLC | 141,915 | $9,267 |
| Polar Capital Holdings Plc | 105,750 | $6,905 |
| GEODE CAPITAL MANAGEMENT, LLC | 99,007 | $6,466 |
| Deep Track Capital, LP | 95,408 | $6,230 |
| Vivo Capital, LLC | 90,500 | $5,910 |
| STATE STREET CORP | 83,989 | $5,484 |
| MILLENNIUM MANAGEMENT LLC | 76,674 | $5,007 |
| Bank of New York Mellon Corp | 64,857 | $4,235 |
| Alyeska Investment Group, L.P. | 40,000 | $2,612 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 33,715 | $2,202 |
| NEUBERGER BERMAN GROUP LLC | 32,547 | $2,125 |
| BALYASNY ASSET MANAGEMENT L.P. | 31,907 | $2,084 |
| NORTHERN TRUST CORP | 30,488 | $1,991 |
| MORGAN STANLEY | 26,967 | $1,761 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,727 | $1 |
| BARCLAYS PLC | 20,245 | $1,322 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 14,285 | $933 |
| CITIGROUP INC | 13,840 | $904 |
| RENAISSANCE TECHNOLOGIES LLC | 11,431 | $746 |
| EAM Investors, LLC | 11,373 | $743 |
| Squarepoint Ops LLC | 10,521 | $687 |
| GOLDMAN SACHS GROUP INC | 10,361 | $677 |
| Virtu Financial LLC | 10,009 | $1 |
| SEI INVESTMENTS CO | 6,926 | $452 |
| BANK OF AMERICA CORP /DE/ | 6,363 | $416 |
| MOUNTAIN PACIFIC INVESTMENT ADVISERS INC/ID | 6,100 | $398 |
| STATE OF WISCONSIN INVESTMENT BOARD | 5,757 | $376 |
| GERBER, LLC | 5,601 | $366 |
| Nuveen, LLC | 5,551 | $362 |
| WELLS FARGO & COMPANY/MN | 5,125 | $335 |
| CITADEL ADVISORS LLC | 5,073 | $331 |
| RHUMBLINE ADVISERS | 4,990 | $326 |
| TWO SIGMA INVESTMENTS, LP | 4,989 | $326 |
| Engineers Gate Manager LP | 4,338 | $283 |
| UBS Group AG | 4,250 | $278 |
| Trexquant Investment LP | 3,778 | $247 |
| Virtus Investment Advisers, LLC | 3,565 | $233 |
| DEUTSCHE BANK AG\ | 3,373 | $220 |
| Invesco Ltd. | 3,355 | $219 |
| TD Asset Management Inc | 3,084 | $201 |
| Caitong International Asset Management Co., Ltd | 2,879 | $188 |
| MetLife Investment Management, LLC | 2,538 | $166 |
| JPMORGAN CHASE & CO | 2,109 | $138 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,090 | $136 |
| AlphaQuest LLC | 1,983 | $129 |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,400 | $91 |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,200 | $78 |
| BNP PARIBAS ARBITRAGE, SA | 1,015 | $66 |
| MEEDER ASSET MANAGEMENT INC | 994 | $65 |
| Police & Firemen's Retirement System of New Jersey | 964 | $63 |
| NewEdge Advisors, LLC | 600 | $39 |
| Legal & General Group Plc | 479 | $31 |
| FMR LLC | 358 | $23 |
| Tower Research Capital LLC (TRC) | 347 | $23 |
| Russell Investments Group, Ltd. | 341 | $22 |
| ROYAL BANK OF CANADA | 326 | $22 |
| Ameritas Investment Partners, Inc. | 300 | $20 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 281 | $18 |
| AMALGAMATED BANK | 144 | $0 |
| Allworth Financial LP | 100 | $7 |
| Sterling Capital Management LLC | 29 | $2 |
| GAMMA Investing LLC | 14 | $1 |
| CWM, LLC | 5 | $0 |