MONOPAR THERAPEUTICS INC

Ticker: MNPR CUSIP: 61023L207 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,989 Value ($000) $326 Avg Close $81.71 Range $63.73 - $105.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,989	$326	$81.71	$63.73 - $105.00