MOONLAKE IMMUNOTHERAPEUTICS

Ticker: MLTX CUSIP: 61559X104 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 784,811 Value ($000) $10,344 Avg Close $11.80 Range $6.56 - $15.55

Q3 2025

Shares 454,268 Value ($000) $3,257 Avg Close $52.12 Range $5.95 - $62.75

Q1 2025

Shares 35,638 Value ($000) $1,392 Avg Close $43.09 Range $36.52 - $56.00

Q4 2023

Shares 3,853 Value ($000) $233 Avg Close $51.54 Range $35.11 - $63.77

Q3 2023

Shares 3,853 Value ($000) $220 Avg Close $55.20 Range $47.33 - $63.40

Q4 2022

Shares 12,385 Value ($000) $130 Avg Close $8.89 Range $7.05 - $10.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	784,811	$10,344	$11.80	$6.56 - $15.55
Q3 2025	454,268	$3,257	$52.12	$5.95 - $62.75
Q1 2025	35,638	$1,392	$43.09	$36.52 - $56.00
Q4 2023	3,853	$233	$51.54	$35.11 - $63.77
Q3 2023	3,853	$220	$55.20	$47.33 - $63.40
Q4 2022	12,385	$130	$8.89	$7.05 - $10.60