| BVF INC/IL | 19,751,284 | $260,322 |
| Deep Track Capital, LP | 4,610,071 | $60,761 |
| Cormorant Asset Management, LP | 4,355,433 | $57,405 |
| D. E. Shaw & Co., Inc. | 2,480,767 | $32,697 |
| JANUS HENDERSON GROUP PLC | 2,095,988 | $27,657 |
| Logos Global Management LP | 1,750,000 | $23,065 |
| JANE STREET GROUP, LLC | 1,682,148 | $22,171 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,571,071 | $20,707 |
| MORGAN STANLEY | 1,044,581 | $13,768 |
| Vivo Capital, LLC | 1,000,000 | $13,180 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 959,553 | $13 |
| JPMORGAN CHASE & CO | 837,739 | $11,041 |
| MILLENNIUM MANAGEMENT LLC | 802,722 | $10,580 |
| TWO SIGMA INVESTMENTS, LP | 784,811 | $10,344 |
| Point72 Asset Management, L.P. | 772,500 | $10,182 |
| Nuveen, LLC | 637,434 | $8,401 |
| HRT FINANCIAL LP | 635,901 | $8 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549,236 | $7,239 |
| Jefferies Financial Group Inc. | 500,000 | $6,590 |
| Voleon Capital Management LP | 499,099 | $6,578 |
| Jump Financial, LLC | 425,559 | $5,609 |
| Soleus Capital Management, L.P. | 400,000 | $5,272 |
| CITADEL ADVISORS LLC | 380,890 | $5,020 |
| Rhenman & Partners Asset Management AB | 364,000 | $4,798 |
| STEMPOINT CAPITAL LP | 348,401 | $4,592 |
| Weiss Asset Management LP | 332,961 | $4,388 |
| Schonfeld Strategic Advisors LLC | 322,261 | $4,247 |
| BlackRock, Inc. | 286,593 | $3,777 |
| Boxer Capital Management, LLC | 275,000 | $3,625 |
| GOLDMAN SACHS GROUP INC | 270,665 | $3,567 |
| VANGUARD GROUP INC | 266,150 | $3,508 |
| First Turn Management, LLC | 262,643 | $3,462 |
| Susquehanna Portfolio Strategies, LLC | 253,974 | $3,347 |
| UBS Group AG | 239,020 | $3,150 |
| ALGERT GLOBAL LLC | 221,616 | $3 |
| ExodusPoint Capital Management, LP | 212,996 | $2,807 |
| Granahan Investment Management, LLC | 198,307 | $2,614 |
| Eagle Health Investments LP | 187,600 | $2,473 |
| Trexquant Investment LP | 184,319 | $2,429 |
| DIMENSIONAL FUND ADVISORS LP | 183,552 | $2,419 |
| Kalehua Capital Management LLC | 175,734 | $2,316 |
| FMR LLC | 156,276 | $2,060 |
| RENAISSANCE TECHNOLOGIES LLC | 134,472 | $1,772 |
| Candriam S.C.A. | 134,329 | $1,771 |
| TWO SIGMA ADVISERS, LP | 131,700 | $1,736 |
| AMERIPRISE FINANCIAL INC | 130,964 | $1,726 |
| RICE HALL JAMES & ASSOCIATES, LLC | 127,465 | $1,680 |
| TD Asset Management Inc | 126,744 | $1,670 |
| Squarepoint Ops LLC | 121,640 | $1,603 |
| TUDOR INVESTMENT CORP ET AL | 103,516 | $1,364 |
| J. Goldman & Co LP | 101,467 | $1,337 |
| Y-Intercept (Hong Kong) Ltd | 95,972 | $1,265 |
| GSA CAPITAL PARTNERS LLP | 89,236 | $1 |
| Walleye Trading LLC | 87,390 | $1,152 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85,570 | $1,130 |
| Brevan Howard Capital Management LP | 78,638 | $1,036 |
| Walleye Capital LLC | 75,752 | $998 |
| GEODE CAPITAL MANAGEMENT, LLC | 72,606 | $956 |
| FOX RUN MANAGEMENT, L.L.C. | 71,962 | $948 |
| CONGRESS ASSET MANAGEMENT CO /MA | 71,096 | $937 |
| Jain Global LLC | 70,611 | $931 |
| Lion Point Capital, LP | 67,500 | $890 |
| BNP Paribas Investment Partners S.A. | 61,948 | $1 |
| Rock Springs Capital Management LP | 61,700 | $813 |
| Swiss National Bank | 61,500 | $811 |
| ACUTA CAPITAL PARTNERS, LLC | 59,280 | $781 |
| ALPS ADVISORS INC | 58,169 | $767 |
| STATE STREET CORP | 50,973 | $672 |
| BARCLAYS PLC | 50,251 | $662 |
| Quadrature Capital Ltd | 50,217 | $662 |
| Woodline Partners LP | 49,168 | $648 |
| Cinctive Capital Management LP | 37,194 | $490 |
| IMC-Chicago, LLC | 36,468 | $481 |
| AQR CAPITAL MANAGEMENT LLC | 32,886 | $433 |
| GROUP ONE TRADING, L.P. | 30,476 | $402 |
| Entropy Technologies, LP | 30,300 | $399 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,296 | $386 |
| SIMPLEX TRADING, LLC | 28,972 | $382 |
| AXIOM INVESTORS LLC /DE | 25,998 | $343 |
| Graham Capital Management, L.P. | 24,292 | $320 |
| XTX Topco Ltd | 22,973 | $303 |
| SG Americas Securities, LLC | 21,888 | $0 |
| Mariner, LLC | 20,159 | $266 |
| NORTHERN TRUST CORP | 18,479 | $244 |
| Virtus Investment Advisers, LLC | 17,987 | $237 |
| Legal & General Group Plc | 16,078 | $212 |
| Vident Advisory, LLC | 15,444 | $204 |
| Brooklyn Investment Group | 14,920 | $204 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,592 | $179 |
| BANK OF AMERICA CORP /DE/ | 13,533 | $178 |
| Campbell & CO Investment Adviser LLC | 13,448 | $177 |
| Virtu Financial LLC | 12,582 | $0 |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,438 | $164 |
| Centiva Capital, LP | 12,291 | $162 |
| BNP PARIBAS ARBITRAGE, SA | 11,310 | $149 |
| HSBC HOLDINGS PLC | 11,095 | $147 |
| WELLS FARGO & COMPANY/MN | 10,000 | $132 |
| OSAIC HOLDINGS, INC. | 8,985 | $118 |
| Persistent Asset Partners Ltd | 8,523 | $112 |
| Caitong International Asset Management Co., Ltd | 6,950 | $92 |
| 29 other institutions | 49,920 | $611 |