NEKTAR THERAPEUTICS

Ticker: NKTR CUSIP: 640268306 Class: COM NEW

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 473,014 Value ($000) $19,999 Avg Close $55.96 Range $41.32 - $66.92

Q3 2025

Shares 434,237 Value ($000) $24,708 Avg Close $33.10 Range $21.02 - $61.15

Q2 2025

Shares 79,395 Value ($000) $2,052 Avg Close $11.24 Range $6.45 - $37.38

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	473,014	$19,999	$55.96	$41.32 - $66.92
Q3 2025	434,237	$24,708	$33.10	$21.02 - $61.15
Q2 2025	79,395	$2,052	$11.24	$6.45 - $37.38