| BVF INC/IL | 1,559,595 | $65,940 |
| VANGUARD GROUP INC | 1,027,089 | $43,425 |
| Two Seas Capital LP | 745,185 | $31,506 |
| BlackRock, Inc. | 645,607 | $27,296 |
| ARMISTICE CAPITAL, LLC | 596,000 | $25,199 |
| MORGAN STANLEY | 566,421 | $23,948 |
| Prosight Management, LP | 554,633 | $23,450 |
| TWO SIGMA INVESTMENTS, LP | 473,014 | $19,999 |
| Invesco Ltd. | 468,159 | $19,794 |
| MILLENNIUM MANAGEMENT LLC | 454,075 | $19,198 |
| Sofinnova Investments, Inc. | 438,630 | $18,545 |
| Point72 Asset Management, L.P. | 433,419 | $18,325 |
| EMERALD ADVISERS, LLC | 384,342 | $16,250 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 383,310 | $16,206 |
| 22NW, LP | 331,115 | $14,000 |
| Qube Research & Technologies Ltd | 323,915 | $13,695 |
| CITADEL ADVISORS LLC | 309,777 | $13,097 |
| TWO SIGMA ADVISERS, LP | 308,414 | $13,040 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 295,716 | $12,503 |
| UBS Group AG | 287,561 | $12,158 |
| BALYASNY ASSET MANAGEMENT L.P. | 282,021 | $11,924 |
| PRIMECAP MANAGEMENT CO/CA/ | 280,150 | $11,845 |
| GEODE CAPITAL MANAGEMENT, LLC | 254,361 | $10,758 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 253,125 | $10,702 |
| JANE STREET GROUP, LLC | 218,337 | $9,231 |
| GREAT POINT PARTNERS LLC | 210,732 | $8,910 |
| BNP PARIBAS ARBITRAGE, SA | 210,298 | $8,891 |
| GILDER GAGNON HOWE & CO LLC | 208,302 | $8,807 |
| STATE STREET CORP | 195,656 | $8,272 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 188,112 | $7,953 |
| Creek Drive Management Group LLC | 185,500 | $7,843 |
| STEMPOINT CAPITAL LP | 178,274 | $7,537 |
| HRT FINANCIAL LP | 173,443 | $7 |
| RENAISSANCE TECHNOLOGIES LLC | 172,881 | $7,309 |
| JPMORGAN CHASE & CO | 150,804 | $6,376 |
| GOLDMAN SACHS GROUP INC | 147,793 | $6,249 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,380 | $5,090 |
| Nantahala Capital Management, LLC | 112,946 | $4,775 |
| Jefferies Financial Group Inc. | 111,900 | $4,731 |
| Woodline Partners LP | 104,000 | $4,397 |
| Connor, Clark & Lunn Investment Management Ltd. | 101,166 | $4,277 |
| FMR LLC | 101,129 | $4,276 |
| ING GROEP NV | 100,000 | $4,228 |
| Monashee Investment Management LLC | 94,134 | $3,980 |
| DEUTSCHE BANK AG\ | 90,743 | $3,837 |
| Quinn Opportunity Partners LLC | 85,868 | $3,630 |
| Russell Investments Group, Ltd. | 85,666 | $3,622 |
| Stonepine Capital Management, LLC | 85,000 | $3,594 |
| Propel Bio Management, LLC | 82,822 | $3,502 |
| DAFNA Capital Management LLC | 74,998 | $3,171 |
| ACADIAN ASSET MANAGEMENT LLC | 72,241 | $3 |
| ADAR1 Capital Management, LLC | 72,031 | $3,045 |
| Tetragon Partners GP Ltd | 69,287 | $2,929 |
| Voleon Capital Management LP | 68,335 | $2,889 |
| Nearwater Capital Markets, Ltd | 61,500 | $2,600 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 60,431 | $2,555 |
| Hudson Bay Capital Management LP | 59,691 | $2,524 |
| F/M Investments LLC | 58,123 | $2,457 |
| NORTHERN TRUST CORP | 56,076 | $2,371 |
| Moody Aldrich Partners LLC | 56,023 | $2,369 |
| Aquatic Capital Management LLC | 55,240 | $2,336 |
| FRED ALGER MANAGEMENT, LLC | 54,020 | $2,284 |
| Cambridge Investment Research Advisors, Inc. | 53,713 | $2 |
| Jump Financial, LLC | 53,212 | $2,250 |
| ACT CAPITAL MANAGEMENT, LLC | 51,200 | $2,165 |
| NORGES BANK | 50,000 | $2,114 |
| DARK FOREST CAPITAL MANAGEMENT LP | 42,277 | $1,787 |
| Headlands Technologies LLC | 41,201 | $1,742 |
| AWM Investment Company, Inc. | 40,000 | $1,691 |
| Deuterium Capital Management, LLC | 37,349 | $1,579 |
| Engineers Gate Manager LP | 37,284 | $1,576 |
| CITIGROUP INC | 35,777 | $1,513 |
| Caption Management, LLC | 35,000 | $1,480 |
| Swiss National Bank | 31,900 | $1,349 |
| SummitTX Capital, L.P. | 31,353 | $1,326 |
| Birchview Capital, LP | 31,000 | $1,311 |
| Simplify Asset Management Inc. | 28,000 | $1,184 |
| Erste Asset Management GmbH | 28,000 | $1,196 |
| KVP Capital Advisors, LP | 26,900 | $1,137 |
| FOX RUN MANAGEMENT, L.L.C. | 26,522 | $1,121 |
| BANK OF AMERICA CORP /DE/ | 26,092 | $1,103 |
| MARSHALL WACE, LLP | 24,023 | $1,016 |
| GSA CAPITAL PARTNERS LLP | 23,114 | $1 |
| SIMPLEX TRADING, LLC | 21,936 | $927 |
| BIT Capital GmbH | 21,100 | $892 |
| Squarepoint Ops LLC | 20,257 | $856 |
| Ishara Investments LP | 20,000 | $846 |
| Trexquant Investment LP | 18,821 | $796 |
| J. Goldman & Co LP | 18,352 | $776 |
| Jain Global LLC | 17,299 | $731 |
| UBS ASSET MANAGEMENT AMERICAS INC | 16,184 | $684 |
| Susquehanna Portfolio Strategies, LLC | 16,057 | $679 |
| Knott David M Jr | 15,500 | $655 |
| BARCLAYS PLC | 15,444 | $653 |
| ALGERT GLOBAL LLC | 15,310 | $1 |
| Seven Fleet Capital Management LP | 15,000 | $634 |
| Palumbo Wealth Management LLC | 14,714 | $622 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 14,564 | $616 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,520 | $614 |
| Virtu Financial LLC | 13,811 | $1 |
| 71 other institutions | 279,113 | $10,557 |