NEUROGENE INC

Ticker: NGNE CUSIP: 64135M105 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,991 Value ($000) $247 Avg Close $24.89 Range $17.29 - $37.27

Q3 2025

Shares 20,551 Value ($000) $356 Avg Close $20.08 Range $14.65 - $23.88

Q2 2025

Shares 20,497 Value ($000) $306 Avg Close $15.69 Range $6.88 - $25.19

Q1 2025

Shares 10,844 Value ($000) $127 Avg Close $17.37 Range $11.02 - $26.48

Q4 2024

Shares 20,629 Value ($000) $472 Avg Close $37.21 Range $14.44 - $74.49

Q1 2024

Shares 3,961 Value ($000) $202 Avg Close $33.40 Range $19.00 - $53.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,991	$247	$24.89	$17.29 - $37.27
Q3 2025	20,551	$356	$20.08	$14.65 - $23.88
Q2 2025	20,497	$306	$15.69	$6.88 - $25.19
Q1 2025	10,844	$127	$17.37	$11.02 - $26.48
Q4 2024	20,629	$472	$37.21	$14.44 - $74.49
Q1 2024	3,961	$202	$33.40	$19.00 - $53.00