| Samsara BioCapital, LLC | 1,717,127 | $35,373 |
| Redmile Group, LLC | 1,459,599 | $30,068 |
| RTW INVESTMENTS, LP | 1,362,456 | $28,067 |
| Casdin Capital, LLC | 1,295,361 | $26,684 |
| EcoR1 Capital, LLC | 1,271,342 | $26,190 |
| BAKER BROS. ADVISORS LP | 991,691 | $20,429 |
| BlackRock, Inc. | 945,583 | $19,479 |
| Trails Edge Capital Partners, LP | 785,000 | $16,171 |
| TORONTO DOMINION BANK | 681,337 | $14,036 |
| VANGUARD GROUP INC | 656,572 | $13,525 |
| BALYASNY ASSET MANAGEMENT L.P. | 608,578 | $12,537 |
| ArrowMark Colorado Holdings LLC | 577,490 | $11,896 |
| JENNISON ASSOCIATES LLC | 533,088 | $10,982 |
| MORGAN STANLEY | 371,174 | $7,646 |
| CITADEL ADVISORS LLC | 364,228 | $7,503 |
| GREAT POINT PARTNERS LLC | 350,000 | $7,210 |
| STATE STREET CORP | 307,797 | $6,341 |
| GEODE CAPITAL MANAGEMENT, LLC | 249,695 | $5,145 |
| Logos Global Management LP | 195,000 | $4,017 |
| BLAIR WILLIAM & CO/IL | 163,655 | $3,371 |
| GOLDMAN SACHS GROUP INC | 162,018 | $3,338 |
| UBS Group AG | 154,123 | $3,175 |
| FMR LLC | 130,329 | $2,685 |
| Rock Springs Capital Management LP | 104,339 | $2,149 |
| DEUTSCHE BANK AG\ | 85,571 | $1,763 |
| NORTHERN TRUST CORP | 85,559 | $1,763 |
| Woodline Partners LP | 83,835 | $1,727 |
| MILLENNIUM MANAGEMENT LLC | 71,321 | $1,469 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 52,300 | $1,156 |
| Trexquant Investment LP | 43,323 | $892 |
| Raiffeisen Bank International AG | 42,000 | $929 |
| BANK OF AMERICA CORP /DE/ | 41,759 | $860 |
| D. E. Shaw & Co., Inc. | 40,347 | $831 |
| Walleye Capital LLC | 36,102 | $744 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 32,765 | $675 |
| Squarepoint Ops LLC | 32,489 | $669 |
| ADAR1 Capital Management, LLC | 30,633 | $631 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,959 | $617 |
| ExodusPoint Capital Management, LP | 29,119 | $600 |
| DAFNA Capital Management LLC | 27,974 | $576 |
| Schonfeld Strategic Advisors LLC | 27,894 | $575 |
| Bank of New York Mellon Corp | 23,093 | $476 |
| Nuveen, LLC | 21,093 | $435 |
| AMERICAN CENTURY COMPANIES INC | 17,560 | $362 |
| BARCLAYS PLC | 15,375 | $317 |
| JANE STREET GROUP, LLC | 15,105 | $311 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,530 | $482 |
| RENAISSANCE TECHNOLOGIES LLC | 14,000 | $288 |
| RHUMBLINE ADVISERS | 13,383 | $276 |
| ALPS ADVISORS INC | 12,721 | $262 |
| Virtus Investment Advisers, LLC | 12,716 | $262 |
| TWO SIGMA INVESTMENTS, LP | 11,991 | $247 |
| DIMENSIONAL FUND ADVISORS LP | 11,410 | $235 |
| WELLS FARGO & COMPANY/MN | 11,037 | $227 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 10,781 | $222 |
| ALLIANCEBERNSTEIN L.P. | 10,570 | $218 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 8,192 | $165 |
| AlphaQuest LLC | 7,215 | $149 |
| MetLife Investment Management, LLC | 5,932 | $122 |
| JPMORGAN CHASE & CO | 5,363 | $110 |
| PNC Financial Services Group, Inc. | 5,124 | $106 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,591 | $95 |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | $87 |
| Daiwa Securities Group Inc. | 3,227 | $0 |
| China Universal Asset Management Co., Ltd. | 2,524 | $52 |
| BNP PARIBAS ARBITRAGE, SA | 2,424 | $50 |
| Police & Firemen's Retirement System of New Jersey | 2,013 | $41 |
| Tower Research Capital LLC (TRC) | 1,233 | $25 |
| Ameritas Investment Partners, Inc. | 1,009 | $21 |
| Leonteq Securities AG | 1,000 | $21 |
| Legal & General Group Plc | 898 | $18 |
| Russell Investments Group, Ltd. | 856 | $18 |
| CITIGROUP INC | 754 | $16 |
| Mirae Asset Global Investments Co., Ltd. | 753 | $16 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 606 | $12 |
| Sterling Capital Management LLC | 567 | $12 |
| ROYAL BANK OF CANADA | 430 | $9 |
| GAMMA Investing LLC | 408 | $8 |
| AMALGAMATED BANK | 309 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 302 | $6 |
| US BANCORP \DE\ | 163 | $3 |
| CWM, LLC | 154 | $0 |
| SIMPLEX TRADING, LLC | 62 | $1 |
| Optiver Holding B.V. | 61 | $1 |
| Truvestments Capital LLC | 46 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 45 | $1 |
| SageView Advisory Group, LLC | 45 | $1 |
| EverSource Wealth Advisors, LLC | 44 | $1 |
| ROTHSCHILD INVESTMENT LLC | 40 | $1 |
| Versant Capital Management, Inc | 33 | $1 |
| SBI Securities Co., Ltd. | 25 | $1 |
| NATIONAL BANK OF CANADA /FI/ | 8 | $0 |
| SRS Capital Advisors, Inc. | 2 | $0 |