NIVALIS THERAPEUTICS INC

CUSIP: 65481J109 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 204,700 Value ($000) $1,664 Avg Close — Range —
Q1 2016
Shares 79,900 Value ($000) $333 Avg Close — Range —
Q4 2015
Shares 231,548 Value ($000) $1,792 Avg Close — Range —
Q3 2015
Shares 201,720 Value ($000) $2,616 Avg Close — Range —
Q2 2015
Shares 255,000 Value ($000) $3,863 Avg Close — Range —