NIVALIS THERAPEUTICS INC

CUSIP: 65481J109 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 100,000 Value ($000) $417 Avg Close — Range —
Q3 2015
Shares 175,200 Value ($000) $2,272 Avg Close — Range —