OPHTHOTECH CORP

CUSIP: 683745103 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 80,000 Value ($000) $3,382 Avg Close — Range —
Q4 2015
Shares 105,000 Value ($000) $8,246 Avg Close — Range —
Q3 2015
Shares 105,000 Value ($000) $4,255 Avg Close — Range —
Q2 2015
Shares 105,000 Value ($000) $5,487 Avg Close — Range —
Q1 2015
Shares 105,000 Value ($000) $4,886 Avg Close — Range —
Q4 2014
Shares 100,000 Value ($000) $4,487 Avg Close — Range —
Q3 2014
Shares 35,000 Value ($000) $1,362,550 Avg Close — Range —