OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,692,650 Value ($000) $4,653 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 3,768,934 Value ($000) $5,842 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 3,350,376 Value ($000) $4,422 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 2,741,986 Value ($000) $4,552 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 3,497,406 Value ($000) $5,141 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 4,212,355 Value ($000) $6,276 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 5,047,924 Value ($000) $6,310 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 5,809,298 Value ($000) $6,971 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 5,733,700 Value ($000) $8,658 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 5,549,946 Value ($000) $8,880 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 5,144,840 Value ($000) $11,164 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 4,847,740 Value ($000) $7,078 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 4,374,623 Value ($000) $5,468 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 3,813,530 Value ($000) $7,208 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 3,392,673 Value ($000) $8,584 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 3,870,903 Value ($000) $13,316 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 3,574,865 Value ($000) $17,196 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 3,550,759 Value ($000) $12,961 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 3,641,656 Value ($000) $14,749 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 3,615,342 Value ($000) $15,510 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 3,528,264 Value ($000) $13,937 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 3,291,611 Value ($000) $12,147 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 2,727,408 Value ($000) $9,301 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 2,512,737 Value ($000) $3,368 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 2,462,420 Value ($000) $3,620 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 2,437,149 Value ($000) $5,094 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 2,387,816 Value ($000) $5,827 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 2,259,566 Value ($000) $5,898 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 2,100,496 Value ($000) $6,323 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 2,103,193 Value ($000) $7,278 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 2,395,831 Value ($000) $11,261 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 1,607,078 Value ($000) $5,095 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 1,562,004 Value ($000) $7,654 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 1,566,433 Value ($000) $10,746 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 1,095,177 Value ($000) $7,207 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 905,739 Value ($000) $7,246 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 943,048 Value ($000) $8,771 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 853,806 Value ($000) $9,042 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 784,260 Value ($000) $7,325 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 1,083,462 Value ($000) $11,258 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 1,070,595 Value ($000) $10,760 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 632,368 Value ($000) $5,319 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 440,273 Value ($000) $7,080 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 675,866 Value ($000) $9,578 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 639,087 Value ($000) $6,385 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 617,334 Value ($000) $5,254 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 615,533 Value ($000) $5,442 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 606,133 Value ($000) $5,650 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 507,617 Value ($000) $4,285 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 479,371 Value ($000) $4,382 Avg Close $8.02 Range $7.13 - $10.00

Q2 2013

Shares 346,458 Value ($000) $2,564 Avg Close $6.91 Range $6.14 - $7.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,692,650	$4,653	$1.39	$1.22 - $1.60
Q3 2025	3,768,934	$5,842	$1.37	$1.11 - $1.55
Q2 2025	3,350,376	$4,422	$1.37	$1.21 - $1.69
Q1 2025	2,741,986	$4,552	$1.65	$1.43 - $2.04
Q4 2024	3,497,406	$5,141	$1.53	$1.37 - $1.76
Q3 2024	4,212,355	$6,276	$1.48	$1.19 - $1.75
Q2 2024	5,047,924	$6,310	$1.30	$1.15 - $1.45
Q1 2024	5,809,298	$6,971	$1.00	$0.85 - $1.57
Q4 2023	5,733,700	$8,658	$1.45	$1.20 - $1.66
Q3 2023	5,549,946	$8,880	$1.82	$1.48 - $2.24
Q2 2023	5,144,840	$11,164	$1.56	$1.34 - $2.24
Q1 2023	4,847,740	$7,078	$1.29	$1.00 - $1.68
Q4 2022	4,374,623	$5,468	$1.58	$1.03 - $2.01
Q3 2022	3,813,530	$7,208	$2.36	$1.78 - $2.86
Q2 2022	3,392,673	$8,584	$2.92	$2.17 - $3.63
Q1 2022	3,870,903	$13,316	$3.53	$2.79 - $4.96
Q4 2021	3,574,865	$17,196	$4.05	$3.49 - $5.25
Q3 2021	3,550,759	$12,961	$3.72	$3.26 - $4.24
Q2 2021	3,641,656	$14,749	$3.92	$3.32 - $4.63
Q1 2021	3,615,342	$15,510	$4.78	$3.83 - $6.27
Q4 2020	3,528,264	$13,937	$4.18	$3.02 - $4.92
Q3 2020	3,291,611	$12,147	$4.22	$2.84 - $6.47
Q2 2020	2,727,408	$9,301	$2.24	$1.12 - $3.52
Q1 2020	2,512,737	$3,368	$1.57	$1.30 - $2.91
Q4 2019	2,462,420	$3,620	$1.67	$1.33 - $2.43
Q3 2019	2,437,149	$5,094	$2.04	$1.75 - $2.53
Q2 2019	2,387,816	$5,827	$2.18	$1.73 - $2.64
Q1 2019	2,259,566	$5,898	$3.03	$2.40 - $3.94
Q4 2018	2,100,496	$6,323	$3.39	$2.34 - $3.92
Q3 2018	2,103,193	$7,278	$5.26	$3.21 - $6.40
Q2 2018	2,395,831	$11,261	$3.79	$2.91 - $5.02
Q1 2018	1,607,078	$5,095	$4.03	$2.66 - $5.14
Q4 2017	1,562,004	$7,654	$5.80	$4.50 - $7.08
Q3 2017	1,566,433	$10,746	$6.31	$5.85 - $7.24
Q2 2017	1,095,177	$7,207	$7.01	$5.99 - $8.04
Q1 2017	905,739	$7,246	$8.42	$7.13 - $9.55
Q4 2016	943,048	$8,771	$10.35	$8.92 - $12.15
Q3 2016	853,806	$9,042	$9.96	$8.91 - $11.31
Q2 2016	784,260	$7,325	$10.16	$8.71 - $11.39
Q1 2016	1,083,462	$11,258	$9.14	$7.12 - $11.85
Q4 2015	1,070,595	$10,760	$10.02	$8.20 - $11.49
Q3 2015	632,368	$5,319	$13.24	$8.23 - $17.51
Q2 2015	440,273	$7,080	$15.55	$13.71 - $19.20
Q1 2015	675,866	$9,578	$13.01	$9.81 - $15.23
Q4 2014	639,087	$6,385	$8.56	$8.02 - $10.16
Q3 2014	617,334	$5,254	$8.79	$8.09 - $9.62
Q2 2014	615,533	$5,442	$8.73	$7.82 - $9.83
Q1 2014	606,133	$5,650	$8.77	$7.32 - $10.25
Q4 2013	507,617	$4,285	$10.11	$8.17 - $12.95
Q3 2013	479,371	$4,382	$8.02	$7.13 - $10.00
Q2 2013	346,458	$2,564	$6.91	$6.14 - $7.65