OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
Rubric Capital Management LP47,791,243$60,217
BlackRock, Inc.34,852,030$43,914
VANGUARD GROUP INC32,457,788$40,897
GEODE CAPITAL MANAGEMENT, LLC11,061,318$13,940
STATE STREET CORP8,951,762$11,279
GOLDMAN SACHS GROUP INC5,986,913$7,544
UBS Group AG5,352,784$6,745
Whitefort Capital Management, LP4,253,340$5,359
CHARLES SCHWAB INVESTMENT MANAGEMENT INC3,692,650$4,653
NORTHERN TRUST CORP3,438,312$4,332
CITADEL ADVISORS LLC2,857,433$3,600
AWM Investment Company, Inc.2,100,000$2,646
AQR CAPITAL MANAGEMENT LLC2,026,957$2,554
JANE STREET GROUP, LLC1,775,336$2,237
DIMENSIONAL FUND ADVISORS LP1,611,318$2,031
WASHINGTON GROWTH STRATEGIES LLC1,356,124$1,709
PFG Investments, LLC1,320,391$1,664
Bank of New York Mellon Corp1,310,094$1,651
Y.D. More Investments Ltd1,306,452$1,671
Voya Investment Management LLC1,102,174$1,389
MORGAN STANLEY917,353$1,156
Clearstead Advisors, LLC882,367$1,112
Tejara Capital Ltd877,941$1,106
Swiss National Bank845,755$1,066
Nuveen, LLC841,836$1,061
Invesco Ltd.781,672$985
TWO SIGMA INVESTMENTS, LP734,747$926
HRT FINANCIAL LP675,483$1
UBS ASSET MANAGEMENT AMERICAS INC673,565$849
BARCLAYS PLC663,236$836
Assenagon Asset Management S.A.652,066$835
COMMONWEALTH EQUITY SERVICES, LLC641,456$808
GSA CAPITAL PARTNERS LLP621,328$1
BANK OF AMERICA CORP /DE/618,259$779
JPMORGAN CHASE & CO579,778$731
RHUMBLINE ADVISERS511,479$644
WELLS FARGO & COMPANY/MN468,518$590
Legal & General Group Plc453,265$571
ALLIANCEBERNSTEIN L.P.448,190$565
SUSQUEHANNA INTERNATIONAL GROUP, LLP437,287$551
Connor, Clark & Lunn Investment Management Ltd.430,630$543
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM417,088$526
TWO SIGMA SECURITIES, LLC374,468$472
CAPITAL ADVISORS INC/OK370,000$25
PRICE T ROWE ASSOCIATES INC /MD/367,191$0
XTX Topco Ltd342,757$432
DEUTSCHE BANK AG\325,889$411
EntryPoint Capital, LLC309,024$389
MILLENNIUM MANAGEMENT LLC265,268$334
ROYAL BANK OF CANADA261,020$329
TUDOR INVESTMENT CORP ET AL244,821$308
MANUFACTURERS LIFE INSURANCE COMPANY, THE229,590$289
JANUS HENDERSON GROUP PLC206,314$259
BALYASNY ASSET MANAGEMENT L.P.198,821$251
MIRABELLA FINANCIAL SERVICES LLP193,722$244
TWO SIGMA ADVISERS, LP191,201$241
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.191,104$241
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM176,260$222
MetLife Investment Management, LLC175,676$221
GAMCO INVESTORS, INC. ET AL175,000$221
GABELLI FUNDS LLC170,000$214
INTECH INVESTMENT MANAGEMENT LLC159,652$201
IEQ CAPITAL, LLC157,779$199
ProShare Advisors LLC156,354$197
ZAZOVE ASSOCIATES LLC150,000$189
Teton Advisors, LLC140,000$176
VAN ECK ASSOCIATES CORP137,019$0
Quantbot Technologies LP122,747$155
COMERICA BANK120,000$151
Graham Capital Management, L.P.119,654$151
HIGHLINE WEALTH PARTNERS LLC116,681$147
Virtu Financial LLC115,298$0
NEW YORK STATE COMMON RETIREMENT FUND114,301$144
Arizona State Retirement System113,834$143
GLENMEDE TRUST CO NA113,483$143
Y-Intercept (Hong Kong) Ltd112,930$142
SIH Partners, LLLP104,334$131
Qube Research & Technologies Ltd102,763$129
Police & Firemen's Retirement System of New Jersey102,397$129
RPg Family Wealth Advisory, LLC98,990$125
AMERIPRISE FINANCIAL INC96,242$121
SIMPLEX TRADING, LLC93,881$118
Quadrature Capital Ltd91,702$116
KLP KAPITALFORVALTNING AS90,700$114
BNP PARIBAS ARBITRAGE, SA90,433$114
Cambridge Investment Research Advisors, Inc.89,721$0
Headlands Technologies LLC88,962$112
360 Financial, Inc.87,300$110
Brevan Howard Capital Management LP85,348$108
OSAIC HOLDINGS, INC.75,315$95
CWM, LLC69,147$0
World Investment Advisors66,520$84
Cascade Financial Partners, LLC66,490$84
Pictet Asset Management Holding SA65,495$83
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO61,502$0
Cetera Investment Advisers59,163$75
MERCER GLOBAL ADVISORS INC /ADV59,026$74
KESTRA PRIVATE WEALTH SERVICES, LLC58,450$74
Creative Planning58,061$73
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC57,529$76
117 other institutions2,083,958$2,422
Total (217 institutions)199,499,005$248,079