OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 229,590 Value ($000) $289 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 236,722 Value ($000) $367 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 138,643 Value ($000) $183 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 124,731 Value ($000) $207 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 130,781 Value ($000) $192 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 134,972 Value ($000) $201 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 138,016 Value ($000) $173 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 164,462 Value ($000) $197 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 234,887 Value ($000) $355 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 241,217 Value ($000) $386 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 169,532 Value ($000) $368 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 166,248 Value ($000) $243 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 174,345 Value ($000) $218 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 170,750 Value ($000) $323 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 172,619 Value ($000) $437 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 172,454 Value ($000) $593 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 208,471 Value ($000) $1,003 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 212,578 Value ($000) $776 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 226,446 Value ($000) $917 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 229,306 Value ($000) $984 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 243,039 Value ($000) $960 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 234,779 Value ($000) $866 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 243,474 Value ($000) $718 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 254,509 Value ($000) $341 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 223,115 Value ($000) $328 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 221,148 Value ($000) $460 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 237,061 Value ($000) $578 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 219,477 Value ($000) $573 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 227,099 Value ($000) $683 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 217,492 Value ($000) $753 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 252,336 Value ($000) $1,187 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 20,326 Value ($000) $65 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 22,405 Value ($000) $110 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 23,423 Value ($000) $161 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 22,535 Value ($000) $149 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 20,878 Value ($000) $167 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 16,094 Value ($000) $149 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 15,603 Value ($000) $165 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 15,603 Value ($000) $146 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 15,732 Value ($000) $156 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 15,207 Value ($000) $153 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 15,207 Value ($000) $128 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 12,932 Value ($000) $208 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 389,179 Value ($000) $5,515 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 470,158 Value ($000) $4,697 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 472,036 Value ($000) $4,017 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 131,005 Value ($000) $1,158 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 148,947 Value ($000) $1,388 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 149,036 Value ($000) $1,258 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 115,854 Value ($000) $1,021 Avg Close $8.02 Range $7.13 - $10.00

Q2 2013

Shares 118,871 Value ($000) $844 Avg Close $6.91 Range $6.14 - $7.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	229,590	$289	$1.39	$1.22 - $1.60
Q3 2025	236,722	$367	$1.37	$1.11 - $1.55
Q2 2025	138,643	$183	$1.37	$1.21 - $1.69
Q1 2025	124,731	$207	$1.65	$1.43 - $2.04
Q4 2024	130,781	$192	$1.53	$1.37 - $1.76
Q3 2024	134,972	$201	$1.48	$1.19 - $1.75
Q2 2024	138,016	$173	$1.30	$1.15 - $1.45
Q1 2024	164,462	$197	$1.00	$0.85 - $1.57
Q4 2023	234,887	$355	$1.45	$1.20 - $1.66
Q3 2023	241,217	$386	$1.82	$1.48 - $2.24
Q2 2023	169,532	$368	$1.56	$1.34 - $2.24
Q1 2023	166,248	$243	$1.29	$1.00 - $1.68
Q4 2022	174,345	$218	$1.58	$1.03 - $2.01
Q3 2022	170,750	$323	$2.36	$1.78 - $2.86
Q2 2022	172,619	$437	$2.92	$2.17 - $3.63
Q1 2022	172,454	$593	$3.53	$2.79 - $4.96
Q4 2021	208,471	$1,003	$4.05	$3.49 - $5.25
Q3 2021	212,578	$776	$3.72	$3.26 - $4.24
Q2 2021	226,446	$917	$3.92	$3.32 - $4.63
Q1 2021	229,306	$984	$4.78	$3.83 - $6.27
Q4 2020	243,039	$960	$4.18	$3.02 - $4.92
Q3 2020	234,779	$866	$4.22	$2.84 - $6.47
Q2 2020	243,474	$718	$2.24	$1.12 - $3.52
Q1 2020	254,509	$341	$1.57	$1.30 - $2.91
Q4 2019	223,115	$328	$1.67	$1.33 - $2.43
Q3 2019	221,148	$460	$2.04	$1.75 - $2.53
Q2 2019	237,061	$578	$2.18	$1.73 - $2.64
Q1 2019	219,477	$573	$3.03	$2.40 - $3.94
Q4 2018	227,099	$683	$3.39	$2.34 - $3.92
Q3 2018	217,492	$753	$5.26	$3.21 - $6.40
Q2 2018	252,336	$1,187	$3.79	$2.91 - $5.02
Q1 2018	20,326	$65	$4.03	$2.66 - $5.14
Q4 2017	22,405	$110	$5.80	$4.50 - $7.08
Q3 2017	23,423	$161	$6.31	$5.85 - $7.24
Q2 2017	22,535	$149	$7.01	$5.99 - $8.04
Q1 2017	20,878	$167	$8.42	$7.13 - $9.55
Q4 2016	16,094	$149	$10.35	$8.92 - $12.15
Q3 2016	15,603	$165	$9.96	$8.91 - $11.31
Q2 2016	15,603	$146	$10.16	$8.71 - $11.39
Q1 2016	15,732	$156	$9.14	$7.12 - $11.85
Q4 2015	15,207	$153	$10.02	$8.20 - $11.49
Q3 2015	15,207	$128	$13.24	$8.23 - $17.51
Q2 2015	12,932	$208	$15.55	$13.71 - $19.20
Q1 2015	389,179	$5,515	$13.01	$9.81 - $15.23
Q4 2014	470,158	$4,697	$8.56	$8.02 - $10.16
Q3 2014	472,036	$4,017	$8.79	$8.09 - $9.62
Q2 2014	131,005	$1,158	$8.73	$7.82 - $9.83
Q1 2014	148,947	$1,388	$8.77	$7.32 - $10.25
Q4 2013	149,036	$1,258	$10.11	$8.17 - $12.95
Q3 2013	115,854	$1,021	$8.02	$7.13 - $10.00
Q2 2013	118,871	$844	$6.91	$6.14 - $7.65