OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

DEUTSCHE BANK AG\'s Holding History (CIK: 0000948046)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 325,889 Value ($000) $411 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 275,188 Value ($000) $427 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 239,018 Value ($000) $316 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 281,647 Value ($000) $468 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 309,867 Value ($000) $456 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 208,999 Value ($000) $311 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 160,271 Value ($000) $200 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 196,768 Value ($000) $236 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 951,120 Value ($000) $1,436 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 228,871 Value ($000) $366 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 1,620,179 Value ($000) $3,516 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 1,738,310 Value ($000) $2,538 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 2,320,513 Value ($000) $2,901 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 2,280,181 Value ($000) $4,310 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 1,528,223 Value ($000) $3,866 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 274,542 Value ($000) $944 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 325,095 Value ($000) $1,564 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 331,969 Value ($000) $1,211 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 335,528 Value ($000) $1,359 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 350,496 Value ($000) $1,503 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 383,204 Value ($000) $1,513 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 296,789 Value ($000) $1,095 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 242,651 Value ($000) $827 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 121,812 Value ($000) $163 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 129,189 Value ($000) $189 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 90,311 Value ($000) $188 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 288,913 Value ($000) $703 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 511,734 Value ($000) $1,334 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 163,736 Value ($000) $491 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 755,425 Value ($000) $2,611 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 836,556 Value ($000) $3,929 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 1,032,259 Value ($000) $3,270 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 199,565 Value ($000) $976 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 1,302,107 Value ($000) $8,929 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 1,126,043 Value ($000) $7,407 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 154,689 Value ($000) $1,235 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 85,740 Value ($000) $794 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 881,449 Value ($000) $9,332 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 1,291,312 Value ($000) $12,058 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 777,547 Value ($000) $8,074 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 115,430 Value ($000) $1,157 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 2,236,965 Value ($000) $18,810 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 1,112,718 Value ($000) $17,891 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 566,023 Value ($000) $8,019 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 744,126 Value ($000) $7,433 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 483,378 Value ($000) $4,113 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 560,439 Value ($000) $4,953 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 805,583 Value ($000) $7,508 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 357,173 Value ($000) $3,014 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 304,591 Value ($000) $2,683 Avg Close $8.02 Range $7.13 - $10.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	325,889	$411	$1.39	$1.22 - $1.60
Q3 2025	275,188	$427	$1.37	$1.11 - $1.55
Q2 2025	239,018	$316	$1.37	$1.21 - $1.69
Q1 2025	281,647	$468	$1.65	$1.43 - $2.04
Q4 2024	309,867	$456	$1.53	$1.37 - $1.76
Q3 2024	208,999	$311	$1.48	$1.19 - $1.75
Q2 2024	160,271	$200	$1.30	$1.15 - $1.45
Q1 2024	196,768	$236	$1.00	$0.85 - $1.57
Q4 2023	951,120	$1,436	$1.45	$1.20 - $1.66
Q3 2023	228,871	$366	$1.82	$1.48 - $2.24
Q2 2023	1,620,179	$3,516	$1.56	$1.34 - $2.24
Q1 2023	1,738,310	$2,538	$1.29	$1.00 - $1.68
Q4 2022	2,320,513	$2,901	$1.58	$1.03 - $2.01
Q3 2022	2,280,181	$4,310	$2.36	$1.78 - $2.86
Q2 2022	1,528,223	$3,866	$2.92	$2.17 - $3.63
Q1 2022	274,542	$944	$3.53	$2.79 - $4.96
Q4 2021	325,095	$1,564	$4.05	$3.49 - $5.25
Q3 2021	331,969	$1,211	$3.72	$3.26 - $4.24
Q2 2021	335,528	$1,359	$3.92	$3.32 - $4.63
Q1 2021	350,496	$1,503	$4.78	$3.83 - $6.27
Q4 2020	383,204	$1,513	$4.18	$3.02 - $4.92
Q3 2020	296,789	$1,095	$4.22	$2.84 - $6.47
Q2 2020	242,651	$827	$2.24	$1.12 - $3.52
Q1 2020	121,812	$163	$1.57	$1.30 - $2.91
Q4 2019	129,189	$189	$1.67	$1.33 - $2.43
Q3 2019	90,311	$188	$2.04	$1.75 - $2.53
Q2 2019	288,913	$703	$2.18	$1.73 - $2.64
Q1 2019	511,734	$1,334	$3.03	$2.40 - $3.94
Q4 2018	163,736	$491	$3.39	$2.34 - $3.92
Q3 2018	755,425	$2,611	$5.26	$3.21 - $6.40
Q2 2018	836,556	$3,929	$3.79	$2.91 - $5.02
Q1 2018	1,032,259	$3,270	$4.03	$2.66 - $5.14
Q4 2017	199,565	$976	$5.80	$4.50 - $7.08
Q3 2017	1,302,107	$8,929	$6.31	$5.85 - $7.24
Q2 2017	1,126,043	$7,407	$7.01	$5.99 - $8.04
Q1 2017	154,689	$1,235	$8.42	$7.13 - $9.55
Q4 2016	85,740	$794	$10.35	$8.92 - $12.15
Q3 2016	881,449	$9,332	$9.96	$8.91 - $11.31
Q2 2016	1,291,312	$12,058	$10.16	$8.71 - $11.39
Q1 2016	777,547	$8,074	$9.14	$7.12 - $11.85
Q4 2015	115,430	$1,157	$10.02	$8.20 - $11.49
Q3 2015	2,236,965	$18,810	$13.24	$8.23 - $17.51
Q2 2015	1,112,718	$17,891	$15.55	$13.71 - $19.20
Q1 2015	566,023	$8,019	$13.01	$9.81 - $15.23
Q4 2014	744,126	$7,433	$8.56	$8.02 - $10.16
Q3 2014	483,378	$4,113	$8.79	$8.09 - $9.62
Q2 2014	560,439	$4,953	$8.73	$7.82 - $9.83
Q1 2014	805,583	$7,508	$8.77	$7.32 - $10.25
Q4 2013	357,173	$3,014	$10.11	$8.17 - $12.95
Q3 2013	304,591	$2,683	$8.02	$7.13 - $10.00