OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM's Holding History (CIK: 0001081019)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 417,088 Value ($000) $526 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 415,386 Value ($000) $644 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 324,117 Value ($000) $428 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 324,117 Value ($000) $538 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 324,117 Value ($000) $476 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 327,817 Value ($000) $488 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 339,056 Value ($000) $424 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 422,677 Value ($000) $507 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 444,922 Value ($000) $672 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 464,561 Value ($000) $743 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 508,114 Value ($000) $1,103 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 591,323 Value ($000) $863 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 596,995 Value ($000) $746 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 540,577 Value ($000) $1,022 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 549,460 Value ($000) $1,390 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 546,710 Value ($000) $1,881 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 592,393 Value ($000) $2,849 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 572,908 Value ($000) $2,091 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 541,949 Value ($000) $2,195 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 599,773 Value ($000) $2,573 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 602,850 Value ($000) $2,381 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 602,167 Value ($000) $2,222 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 599,699 Value ($000) $2,045 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 583,849 Value ($000) $782 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 588,960 Value ($000) $866 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 555,721 Value ($000) $1,161 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 522,993 Value ($000) $1,276 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 496,130 Value ($000) $1,295 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 503,832 Value ($000) $1,517 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 495,513 Value ($000) $1,714 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 492,304 Value ($000) $2,314 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 535,389 Value ($000) $1,697 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 553,474 Value ($000) $2,712 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 551,172 Value ($000) $3,781 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 608,208 Value ($000) $4,002 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 639,957 Value ($000) $5,120 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 669,957 Value ($000) $6,231 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 688,357 Value ($000) $7,290 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 682,157 Value ($000) $6,371 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 642,997 Value ($000) $6,681 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 560,792 Value ($000) $5,636 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 551,894 Value ($000) $4,641 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 428,835 Value ($000) $6,896 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 361,127 Value ($000) $5,117 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 367,327 Value ($000) $3,670 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 363,672 Value ($000) $3,095 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 359,807 Value ($000) $3,181 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 343,107 Value ($000) $3,198 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 341,707 Value ($000) $2,884 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 339,107 Value ($000) $2,988 Avg Close $8.02 Range $7.13 - $10.00

Q2 2013

Shares 247,749 Value ($000) $1,759 Avg Close $6.91 Range $6.14 - $7.65

Q1 2013

Shares 185,692 Value ($000) $1,417 Avg Close $6.69 Range $4.83 - $7.83

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	417,088	$526	$1.39	$1.22 - $1.60
Q3 2025	415,386	$644	$1.37	$1.11 - $1.55
Q2 2025	324,117	$428	$1.37	$1.21 - $1.69
Q1 2025	324,117	$538	$1.65	$1.43 - $2.04
Q4 2024	324,117	$476	$1.53	$1.37 - $1.76
Q3 2024	327,817	$488	$1.48	$1.19 - $1.75
Q2 2024	339,056	$424	$1.30	$1.15 - $1.45
Q1 2024	422,677	$507	$1.00	$0.85 - $1.57
Q4 2023	444,922	$672	$1.45	$1.20 - $1.66
Q3 2023	464,561	$743	$1.82	$1.48 - $2.24
Q2 2023	508,114	$1,103	$1.56	$1.34 - $2.24
Q1 2023	591,323	$863	$1.29	$1.00 - $1.68
Q4 2022	596,995	$746	$1.58	$1.03 - $2.01
Q3 2022	540,577	$1,022	$2.36	$1.78 - $2.86
Q2 2022	549,460	$1,390	$2.92	$2.17 - $3.63
Q1 2022	546,710	$1,881	$3.53	$2.79 - $4.96
Q4 2021	592,393	$2,849	$4.05	$3.49 - $5.25
Q3 2021	572,908	$2,091	$3.72	$3.26 - $4.24
Q2 2021	541,949	$2,195	$3.92	$3.32 - $4.63
Q1 2021	599,773	$2,573	$4.78	$3.83 - $6.27
Q4 2020	602,850	$2,381	$4.18	$3.02 - $4.92
Q3 2020	602,167	$2,222	$4.22	$2.84 - $6.47
Q2 2020	599,699	$2,045	$2.24	$1.12 - $3.52
Q1 2020	583,849	$782	$1.57	$1.30 - $2.91
Q4 2019	588,960	$866	$1.67	$1.33 - $2.43
Q3 2019	555,721	$1,161	$2.04	$1.75 - $2.53
Q2 2019	522,993	$1,276	$2.18	$1.73 - $2.64
Q1 2019	496,130	$1,295	$3.03	$2.40 - $3.94
Q4 2018	503,832	$1,517	$3.39	$2.34 - $3.92
Q3 2018	495,513	$1,714	$5.26	$3.21 - $6.40
Q2 2018	492,304	$2,314	$3.79	$2.91 - $5.02
Q1 2018	535,389	$1,697	$4.03	$2.66 - $5.14
Q4 2017	553,474	$2,712	$5.80	$4.50 - $7.08
Q3 2017	551,172	$3,781	$6.31	$5.85 - $7.24
Q2 2017	608,208	$4,002	$7.01	$5.99 - $8.04
Q1 2017	639,957	$5,120	$8.42	$7.13 - $9.55
Q4 2016	669,957	$6,231	$10.35	$8.92 - $12.15
Q3 2016	688,357	$7,290	$9.96	$8.91 - $11.31
Q2 2016	682,157	$6,371	$10.16	$8.71 - $11.39
Q1 2016	642,997	$6,681	$9.14	$7.12 - $11.85
Q4 2015	560,792	$5,636	$10.02	$8.20 - $11.49
Q3 2015	551,894	$4,641	$13.24	$8.23 - $17.51
Q2 2015	428,835	$6,896	$15.55	$13.71 - $19.20
Q1 2015	361,127	$5,117	$13.01	$9.81 - $15.23
Q4 2014	367,327	$3,670	$8.56	$8.02 - $10.16
Q3 2014	363,672	$3,095	$8.79	$8.09 - $9.62
Q2 2014	359,807	$3,181	$8.73	$7.82 - $9.83
Q1 2014	343,107	$3,198	$8.77	$7.32 - $10.25
Q4 2013	341,707	$2,884	$10.11	$8.17 - $12.95
Q3 2013	339,107	$2,988	$8.02	$7.13 - $10.00
Q2 2013	247,749	$1,759	$6.91	$6.14 - $7.65
Q1 2013	185,692	$1,417	$6.69	$4.83 - $7.83