OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

TANG CAPITAL MANAGEMENT LLC's Holding History (CIK: 0001232621)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016

Shares 350,000 Value ($000) $3,637 Avg Close $9.14 Range $7.12 - $11.85

Q3 2015

Shares 2,475,000 Value ($000) $20,815 Avg Close $13.24 Range $8.23 - $17.51

Q4 2013

Shares 11,195 Value ($000) $94 Avg Close $10.11 Range $8.17 - $12.95

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2016	350,000	$3,637	$9.14	$7.12 - $11.85
Q3 2015	2,475,000	$20,815	$13.24	$8.23 - $17.51
Q4 2013	11,195	$94	$10.11	$8.17 - $12.95