OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 265,268 Value ($000) $334 Avg Close $1.39 Range $1.22 - $1.60

Q2 2025

Shares 695,780 Value ($000) $918 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 6,386,911 Value ($000) $10,602 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 4,588,526 Value ($000) $6,745 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 2,476,144 Value ($000) $3,689 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 1,261,198 Value ($000) $1,576 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 779,430 Value ($000) $935 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 596,444 Value ($000) $901 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 1,113,286 Value ($000) $1,781 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 4,326,865 Value ($000) $9,389 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 6,421,832 Value ($000) $9 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 3,720,447 Value ($000) $5 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 2,142,184 Value ($000) $4,049 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 7,390,435 Value ($000) $18,698 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 1,765,569 Value ($000) $6,074 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 479,760 Value ($000) $2,308 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 479,760 Value ($000) $1,751 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 433,864 Value ($000) $1,757 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 228,652 Value ($000) $981 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 108,266 Value ($000) $428 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 50,971 Value ($000) $188 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 564,873 Value ($000) $1,926 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 3,571,399 Value ($000) $4,786 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 894,625 Value ($000) $1,315 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 455,318 Value ($000) $951 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 2,174,526 Value ($000) $5,306 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 1,215,023 Value ($000) $3,171 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 695,755 Value ($000) $2,094 Avg Close $3.39 Range $2.34 - $3.92

Q1 2018

Shares 2,178,877 Value ($000) $6,907 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 613,661 Value ($000) $3,007 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 514,741 Value ($000) $3,531 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 546,467 Value ($000) $3,596 Avg Close $7.01 Range $5.99 - $8.04

Q3 2016

Shares 82,545 Value ($000) $874 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 902,773 Value ($000) $8,432 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 207,798 Value ($000) $2,159 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 373,664 Value ($000) $3,755 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 292,921 Value ($000) $2,463 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 139,179 Value ($000) $2,238 Avg Close $15.55 Range $13.71 - $19.20

Q4 2014

Shares 69,031 Value ($000) $690 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 75,730 Value ($000) $644 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 218,419 Value ($000) $1,931 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 108,702 Value ($000) $1,013 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 99,438 Value ($000) $839 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 163,750 Value ($000) $1,443 Avg Close $8.02 Range $7.13 - $10.00

Q2 2013

Shares 144,335 Value ($000) $1,025 Avg Close $6.91 Range $6.14 - $7.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	265,268	$334	$1.39	$1.22 - $1.60
Q2 2025	695,780	$918	$1.37	$1.21 - $1.69
Q1 2025	6,386,911	$10,602	$1.65	$1.43 - $2.04
Q4 2024	4,588,526	$6,745	$1.53	$1.37 - $1.76
Q3 2024	2,476,144	$3,689	$1.48	$1.19 - $1.75
Q2 2024	1,261,198	$1,576	$1.30	$1.15 - $1.45
Q1 2024	779,430	$935	$1.00	$0.85 - $1.57
Q4 2023	596,444	$901	$1.45	$1.20 - $1.66
Q3 2023	1,113,286	$1,781	$1.82	$1.48 - $2.24
Q2 2023	4,326,865	$9,389	$1.56	$1.34 - $2.24
Q1 2023	6,421,832	$9	$1.29	$1.00 - $1.68
Q4 2022	3,720,447	$5	$1.58	$1.03 - $2.01
Q3 2022	2,142,184	$4,049	$2.36	$1.78 - $2.86
Q2 2022	7,390,435	$18,698	$2.92	$2.17 - $3.63
Q1 2022	1,765,569	$6,074	$3.53	$2.79 - $4.96
Q4 2021	479,760	$2,308	$4.05	$3.49 - $5.25
Q3 2021	479,760	$1,751	$3.72	$3.26 - $4.24
Q2 2021	433,864	$1,757	$3.92	$3.32 - $4.63
Q1 2021	228,652	$981	$4.78	$3.83 - $6.27
Q4 2020	108,266	$428	$4.18	$3.02 - $4.92
Q3 2020	50,971	$188	$4.22	$2.84 - $6.47
Q2 2020	564,873	$1,926	$2.24	$1.12 - $3.52
Q1 2020	3,571,399	$4,786	$1.57	$1.30 - $2.91
Q4 2019	894,625	$1,315	$1.67	$1.33 - $2.43
Q3 2019	455,318	$951	$2.04	$1.75 - $2.53
Q2 2019	2,174,526	$5,306	$2.18	$1.73 - $2.64
Q1 2019	1,215,023	$3,171	$3.03	$2.40 - $3.94
Q4 2018	695,755	$2,094	$3.39	$2.34 - $3.92
Q1 2018	2,178,877	$6,907	$4.03	$2.66 - $5.14
Q4 2017	613,661	$3,007	$5.80	$4.50 - $7.08
Q3 2017	514,741	$3,531	$6.31	$5.85 - $7.24
Q2 2017	546,467	$3,596	$7.01	$5.99 - $8.04
Q3 2016	82,545	$874	$9.96	$8.91 - $11.31
Q2 2016	902,773	$8,432	$10.16	$8.71 - $11.39
Q1 2016	207,798	$2,159	$9.14	$7.12 - $11.85
Q4 2015	373,664	$3,755	$10.02	$8.20 - $11.49
Q3 2015	292,921	$2,463	$13.24	$8.23 - $17.51
Q2 2015	139,179	$2,238	$15.55	$13.71 - $19.20
Q4 2014	69,031	$690	$8.56	$8.02 - $10.16
Q3 2014	75,730	$644	$8.79	$8.09 - $9.62
Q2 2014	218,419	$1,931	$8.73	$7.82 - $9.83
Q1 2014	108,702	$1,013	$8.77	$7.32 - $10.25
Q4 2013	99,438	$839	$10.11	$8.17 - $12.95
Q3 2013	163,750	$1,443	$8.02	$7.13 - $10.00
Q2 2013	144,335	$1,025	$6.91	$6.14 - $7.65