OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

Choate Investment Advisors's Holding History (CIK: 0001399794)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016

Shares 35,750 Value ($000) $371,443 Avg Close $9.14 Range $7.12 - $11.85

Q3 2015

Shares 35,750 Value ($000) $300,658 Avg Close $13.24 Range $8.23 - $17.51

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2016	35,750	$371,443	$9.14	$7.12 - $11.85
Q3 2015	35,750	$300,658	$13.24	$8.23 - $17.51