OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 191,201 Value ($000) $241 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 344,097 Value ($000) $533 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 648,297 Value ($000) $856 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 551,697 Value ($000) $916 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 381,197 Value ($000) $560 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 372,801 Value ($000) $555 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 462,401 Value ($000) $578 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 1,192,797 Value ($000) $1,431 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 1,136,897 Value ($000) $1,717 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 1,313,097 Value ($000) $2,101 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 1,439,197 Value ($000) $3,123 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 1,797,297 Value ($000) $2,624 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 2,262,997 Value ($000) $2,829 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 2,122,397 Value ($000) $4,011 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 846,797 Value ($000) $2,142 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 342,200 Value ($000) $1,177 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 281,300 Value ($000) $1,353 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 20,300 Value ($000) $74 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 112,900 Value ($000) $457 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 188,900 Value ($000) $810 Avg Close $4.78 Range $3.83 - $6.27

Q2 2020

Shares 908,632 Value ($000) $3,098 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 1,228,332 Value ($000) $1,646 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 435,105 Value ($000) $640 Avg Close $1.67 Range $1.33 - $2.43

Q2 2019

Shares 14,025 Value ($000) $34 Avg Close $2.18 Range $1.73 - $2.64

Q4 2018

Shares 16,400 Value ($000) $49 Avg Close $3.39 Range $2.34 - $3.92

Q2 2015

Shares 81,211 Value ($000) $1,306 Avg Close $15.55 Range $13.71 - $19.20

Q3 2014

Shares 28,600 Value ($000) $243 Avg Close $8.79 Range $8.09 - $9.62

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	191,201	$241	$1.39	$1.22 - $1.60
Q3 2025	344,097	$533	$1.37	$1.11 - $1.55
Q2 2025	648,297	$856	$1.37	$1.21 - $1.69
Q1 2025	551,697	$916	$1.65	$1.43 - $2.04
Q4 2024	381,197	$560	$1.53	$1.37 - $1.76
Q3 2024	372,801	$555	$1.48	$1.19 - $1.75
Q2 2024	462,401	$578	$1.30	$1.15 - $1.45
Q1 2024	1,192,797	$1,431	$1.00	$0.85 - $1.57
Q4 2023	1,136,897	$1,717	$1.45	$1.20 - $1.66
Q3 2023	1,313,097	$2,101	$1.82	$1.48 - $2.24
Q2 2023	1,439,197	$3,123	$1.56	$1.34 - $2.24
Q1 2023	1,797,297	$2,624	$1.29	$1.00 - $1.68
Q4 2022	2,262,997	$2,829	$1.58	$1.03 - $2.01
Q3 2022	2,122,397	$4,011	$2.36	$1.78 - $2.86
Q2 2022	846,797	$2,142	$2.92	$2.17 - $3.63
Q1 2022	342,200	$1,177	$3.53	$2.79 - $4.96
Q4 2021	281,300	$1,353	$4.05	$3.49 - $5.25
Q3 2021	20,300	$74	$3.72	$3.26 - $4.24
Q2 2021	112,900	$457	$3.92	$3.32 - $4.63
Q1 2021	188,900	$810	$4.78	$3.83 - $6.27
Q2 2020	908,632	$3,098	$2.24	$1.12 - $3.52
Q1 2020	1,228,332	$1,646	$1.57	$1.30 - $2.91
Q4 2019	435,105	$640	$1.67	$1.33 - $2.43
Q2 2019	14,025	$34	$2.18	$1.73 - $2.64
Q4 2018	16,400	$49	$3.39	$2.34 - $3.92
Q2 2015	81,211	$1,306	$15.55	$13.71 - $19.20
Q3 2014	28,600	$243	$8.79	$8.09 - $9.62