OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 845,755 Value ($000) $1,066 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 845,755 Value ($000) $1,311 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 577,355 Value ($000) $762 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 661,155 Value ($000) $1,098 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 685,455 Value ($000) $1,008 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 685,455 Value ($000) $1,021 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 685,455 Value ($000) $857 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 837,855 Value ($000) $1,005 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 837,855 Value ($000) $1,265 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 934,055 Value ($000) $1,494 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 925,255 Value ($000) $2,008 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 1,083,955 Value ($000) $1,583 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 1,211,555 Value ($000) $1,514 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 1,047,200 Value ($000) $1,979 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 1,047,200 Value ($000) $2,649 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 1,047,200 Value ($000) $3,602 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 974,300 Value ($000) $4,686 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 960,000 Value ($000) $3,504 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 960,000 Value ($000) $3,888 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 995,000 Value ($000) $4,269 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 986,800 Value ($000) $3,898 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 986,800 Value ($000) $3,641 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 965,700 Value ($000) $3,293 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 710,000 Value ($000) $951 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 648,100 Value ($000) $953 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 635,200 Value ($000) $1,328 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 598,900 Value ($000) $1,467 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 612,200 Value ($000) $1,598 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 593,900 Value ($000) $1,785 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 584,200 Value ($000) $2,015 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 584,200 Value ($000) $2,743 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 584,200 Value ($000) $1,852 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 562,100 Value ($000) $2,754 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 562,100 Value ($000) $3,856 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 562,100 Value ($000) $3,699 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 549,200 Value ($000) $4,394 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 549,200 Value ($000) $5,108 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 539,200 Value ($000) $5,710 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 544,700 Value ($000) $5,087 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 544,700 Value ($000) $5,464 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 433,200 Value ($000) $4,354 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 433,200 Value ($000) $3,643 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 291,400 Value ($000) $4,686 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 266,800 Value ($000) $3,781 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 261,900 Value ($000) $2,616 Avg Close $8.56 Range $8.02 - $10.16

Q3 2014

Shares 249,000 Value ($000) $2,119 Avg Close $8.79 Range $8.09 - $9.62

Q2 2014

Shares 252,000 Value ($000) $2,228 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 252,000 Value ($000) $2,349 Avg Close $8.77 Range $7.32 - $10.25

Q4 2013

Shares 192,800 Value ($000) $1,627 Avg Close $10.11 Range $8.17 - $12.95

Q3 2013

Shares 192,800 Value ($000) $1,699 Avg Close $8.02 Range $7.13 - $10.00

Q2 2013

Shares 129,900 Value ($000) $922 Avg Close $6.91 Range $6.14 - $7.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	845,755	$1,066	$1.39	$1.22 - $1.60
Q3 2025	845,755	$1,311	$1.37	$1.11 - $1.55
Q2 2025	577,355	$762	$1.37	$1.21 - $1.69
Q1 2025	661,155	$1,098	$1.65	$1.43 - $2.04
Q4 2024	685,455	$1,008	$1.53	$1.37 - $1.76
Q3 2024	685,455	$1,021	$1.48	$1.19 - $1.75
Q2 2024	685,455	$857	$1.30	$1.15 - $1.45
Q1 2024	837,855	$1,005	$1.00	$0.85 - $1.57
Q4 2023	837,855	$1,265	$1.45	$1.20 - $1.66
Q3 2023	934,055	$1,494	$1.82	$1.48 - $2.24
Q2 2023	925,255	$2,008	$1.56	$1.34 - $2.24
Q1 2023	1,083,955	$1,583	$1.29	$1.00 - $1.68
Q4 2022	1,211,555	$1,514	$1.58	$1.03 - $2.01
Q3 2022	1,047,200	$1,979	$2.36	$1.78 - $2.86
Q2 2022	1,047,200	$2,649	$2.92	$2.17 - $3.63
Q1 2022	1,047,200	$3,602	$3.53	$2.79 - $4.96
Q4 2021	974,300	$4,686	$4.05	$3.49 - $5.25
Q3 2021	960,000	$3,504	$3.72	$3.26 - $4.24
Q2 2021	960,000	$3,888	$3.92	$3.32 - $4.63
Q1 2021	995,000	$4,269	$4.78	$3.83 - $6.27
Q4 2020	986,800	$3,898	$4.18	$3.02 - $4.92
Q3 2020	986,800	$3,641	$4.22	$2.84 - $6.47
Q2 2020	965,700	$3,293	$2.24	$1.12 - $3.52
Q1 2020	710,000	$951	$1.57	$1.30 - $2.91
Q4 2019	648,100	$953	$1.67	$1.33 - $2.43
Q3 2019	635,200	$1,328	$2.04	$1.75 - $2.53
Q2 2019	598,900	$1,467	$2.18	$1.73 - $2.64
Q1 2019	612,200	$1,598	$3.03	$2.40 - $3.94
Q4 2018	593,900	$1,785	$3.39	$2.34 - $3.92
Q3 2018	584,200	$2,015	$5.26	$3.21 - $6.40
Q2 2018	584,200	$2,743	$3.79	$2.91 - $5.02
Q1 2018	584,200	$1,852	$4.03	$2.66 - $5.14
Q4 2017	562,100	$2,754	$5.80	$4.50 - $7.08
Q3 2017	562,100	$3,856	$6.31	$5.85 - $7.24
Q2 2017	562,100	$3,699	$7.01	$5.99 - $8.04
Q1 2017	549,200	$4,394	$8.42	$7.13 - $9.55
Q4 2016	549,200	$5,108	$10.35	$8.92 - $12.15
Q3 2016	539,200	$5,710	$9.96	$8.91 - $11.31
Q2 2016	544,700	$5,087	$10.16	$8.71 - $11.39
Q1 2016	544,700	$5,464	$9.14	$7.12 - $11.85
Q4 2015	433,200	$4,354	$10.02	$8.20 - $11.49
Q3 2015	433,200	$3,643	$13.24	$8.23 - $17.51
Q2 2015	291,400	$4,686	$15.55	$13.71 - $19.20
Q1 2015	266,800	$3,781	$13.01	$9.81 - $15.23
Q4 2014	261,900	$2,616	$8.56	$8.02 - $10.16
Q3 2014	249,000	$2,119	$8.79	$8.09 - $9.62
Q2 2014	252,000	$2,228	$8.73	$7.82 - $9.83
Q1 2014	252,000	$2,349	$8.77	$7.32 - $10.25
Q4 2013	192,800	$1,627	$10.11	$8.17 - $12.95
Q3 2013	192,800	$1,699	$8.02	$7.13 - $10.00
Q2 2013	129,900	$922	$6.91	$6.14 - $7.65