OPKO HEALTH INC

Ticker: OPK CUSIP: 68375N103 Class: COM

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,775,336 Value ($000) $2,237 Avg Close $1.39 Range $1.22 - $1.60

Q3 2025

Shares 262,838 Value ($000) $407 Avg Close $1.37 Range $1.11 - $1.55

Q2 2025

Shares 1,384,552 Value ($000) $1,828 Avg Close $1.37 Range $1.21 - $1.69

Q1 2025

Shares 549,338 Value ($000) $912 Avg Close $1.65 Range $1.43 - $2.04

Q4 2024

Shares 2,806,921 Value ($000) $4,126 Avg Close $1.53 Range $1.37 - $1.76

Q3 2024

Shares 530,540 Value ($000) $791 Avg Close $1.48 Range $1.19 - $1.75

Q2 2024

Shares 837,579 Value ($000) $1,047 Avg Close $1.30 Range $1.15 - $1.45

Q1 2024

Shares 1,324,822 Value ($000) $1,590 Avg Close $1.00 Range $0.85 - $1.57

Q4 2023

Shares 358,144 Value ($000) $541 Avg Close $1.45 Range $1.20 - $1.66

Q3 2023

Shares 141,775 Value ($000) $227 Avg Close $1.82 Range $1.48 - $2.24

Q2 2023

Shares 535,649 Value ($000) $1,162 Avg Close $1.56 Range $1.34 - $2.24

Q1 2023

Shares 129,287 Value ($000) $189 Avg Close $1.29 Range $1.00 - $1.68

Q4 2022

Shares 639,809 Value ($000) $800 Avg Close $1.58 Range $1.03 - $2.01

Q3 2022

Shares 1,086,733 Value ($000) $2,054 Avg Close $2.36 Range $1.78 - $2.86

Q2 2022

Shares 597,602 Value ($000) $1,512 Avg Close $2.92 Range $2.17 - $3.63

Q1 2022

Shares 539,333 Value ($000) $1,855 Avg Close $3.53 Range $2.79 - $4.96

Q4 2021

Shares 1,342,228 Value ($000) $6,456 Avg Close $4.05 Range $3.49 - $5.25

Q3 2021

Shares 478,653 Value ($000) $1,747 Avg Close $3.72 Range $3.26 - $4.24

Q2 2021

Shares 542,061 Value ($000) $2,195 Avg Close $3.92 Range $3.32 - $4.63

Q1 2021

Shares 708,566 Value ($000) $3,039 Avg Close $4.78 Range $3.83 - $6.27

Q4 2020

Shares 271,180 Value ($000) $1,071 Avg Close $4.18 Range $3.02 - $4.92

Q3 2020

Shares 675,441 Value ($000) $2,492 Avg Close $4.22 Range $2.84 - $6.47

Q2 2020

Shares 1,243,043 Value ($000) $4,238 Avg Close $2.24 Range $1.12 - $3.52

Q1 2020

Shares 712,921 Value ($000) $954 Avg Close $1.57 Range $1.30 - $2.91

Q4 2019

Shares 494,311 Value ($000) $726 Avg Close $1.67 Range $1.33 - $2.43

Q3 2019

Shares 62,695 Value ($000) $131 Avg Close $2.04 Range $1.75 - $2.53

Q2 2019

Shares 259,719 Value ($000) $633 Avg Close $2.18 Range $1.73 - $2.64

Q1 2019

Shares 400,281 Value ($000) $1,045 Avg Close $3.03 Range $2.40 - $3.94

Q4 2018

Shares 531,514 Value ($000) $1,600 Avg Close $3.39 Range $2.34 - $3.92

Q3 2018

Shares 79,742 Value ($000) $276 Avg Close $5.26 Range $3.21 - $6.40

Q2 2018

Shares 149,334 Value ($000) $702 Avg Close $3.79 Range $2.91 - $5.02

Q1 2018

Shares 375,319 Value ($000) $1,190 Avg Close $4.03 Range $2.66 - $5.14

Q4 2017

Shares 356,578 Value ($000) $1,746 Avg Close $5.80 Range $4.50 - $7.08

Q3 2017

Shares 263,011 Value ($000) $1,805 Avg Close $6.31 Range $5.85 - $7.24

Q2 2017

Shares 338,571 Value ($000) $2,228 Avg Close $7.01 Range $5.99 - $8.04

Q1 2017

Shares 491,781 Value ($000) $3,934 Avg Close $8.42 Range $7.13 - $9.55

Q4 2016

Shares 268,246 Value ($000) $2,495 Avg Close $10.35 Range $8.92 - $12.15

Q3 2016

Shares 333,634 Value ($000) $3,533 Avg Close $9.96 Range $8.91 - $11.31

Q2 2016

Shares 98,987 Value ($000) $925 Avg Close $10.16 Range $8.71 - $11.39

Q1 2016

Shares 357,105 Value ($000) $3,710 Avg Close $9.14 Range $7.12 - $11.85

Q4 2015

Shares 272,444 Value ($000) $2,738 Avg Close $10.02 Range $8.20 - $11.49

Q3 2015

Shares 378,110 Value ($000) $3,180 Avg Close $13.24 Range $8.23 - $17.51

Q2 2015

Shares 536,634 Value ($000) $8,629 Avg Close $15.55 Range $13.71 - $19.20

Q1 2015

Shares 159,219 Value ($000) $2,256 Avg Close $13.01 Range $9.81 - $15.23

Q4 2014

Shares 79,418 Value ($000) $793 Avg Close $8.56 Range $8.02 - $10.16

Q2 2014

Shares 218,006 Value ($000) $1,927 Avg Close $8.73 Range $7.82 - $9.83

Q1 2014

Shares 128,484 Value ($000) $1,197 Avg Close $8.77 Range $7.32 - $10.25

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,775,336	$2,237	$1.39	$1.22 - $1.60
Q3 2025	262,838	$407	$1.37	$1.11 - $1.55
Q2 2025	1,384,552	$1,828	$1.37	$1.21 - $1.69
Q1 2025	549,338	$912	$1.65	$1.43 - $2.04
Q4 2024	2,806,921	$4,126	$1.53	$1.37 - $1.76
Q3 2024	530,540	$791	$1.48	$1.19 - $1.75
Q2 2024	837,579	$1,047	$1.30	$1.15 - $1.45
Q1 2024	1,324,822	$1,590	$1.00	$0.85 - $1.57
Q4 2023	358,144	$541	$1.45	$1.20 - $1.66
Q3 2023	141,775	$227	$1.82	$1.48 - $2.24
Q2 2023	535,649	$1,162	$1.56	$1.34 - $2.24
Q1 2023	129,287	$189	$1.29	$1.00 - $1.68
Q4 2022	639,809	$800	$1.58	$1.03 - $2.01
Q3 2022	1,086,733	$2,054	$2.36	$1.78 - $2.86
Q2 2022	597,602	$1,512	$2.92	$2.17 - $3.63
Q1 2022	539,333	$1,855	$3.53	$2.79 - $4.96
Q4 2021	1,342,228	$6,456	$4.05	$3.49 - $5.25
Q3 2021	478,653	$1,747	$3.72	$3.26 - $4.24
Q2 2021	542,061	$2,195	$3.92	$3.32 - $4.63
Q1 2021	708,566	$3,039	$4.78	$3.83 - $6.27
Q4 2020	271,180	$1,071	$4.18	$3.02 - $4.92
Q3 2020	675,441	$2,492	$4.22	$2.84 - $6.47
Q2 2020	1,243,043	$4,238	$2.24	$1.12 - $3.52
Q1 2020	712,921	$954	$1.57	$1.30 - $2.91
Q4 2019	494,311	$726	$1.67	$1.33 - $2.43
Q3 2019	62,695	$131	$2.04	$1.75 - $2.53
Q2 2019	259,719	$633	$2.18	$1.73 - $2.64
Q1 2019	400,281	$1,045	$3.03	$2.40 - $3.94
Q4 2018	531,514	$1,600	$3.39	$2.34 - $3.92
Q3 2018	79,742	$276	$5.26	$3.21 - $6.40
Q2 2018	149,334	$702	$3.79	$2.91 - $5.02
Q1 2018	375,319	$1,190	$4.03	$2.66 - $5.14
Q4 2017	356,578	$1,746	$5.80	$4.50 - $7.08
Q3 2017	263,011	$1,805	$6.31	$5.85 - $7.24
Q2 2017	338,571	$2,228	$7.01	$5.99 - $8.04
Q1 2017	491,781	$3,934	$8.42	$7.13 - $9.55
Q4 2016	268,246	$2,495	$10.35	$8.92 - $12.15
Q3 2016	333,634	$3,533	$9.96	$8.91 - $11.31
Q2 2016	98,987	$925	$10.16	$8.71 - $11.39
Q1 2016	357,105	$3,710	$9.14	$7.12 - $11.85
Q4 2015	272,444	$2,738	$10.02	$8.20 - $11.49
Q3 2015	378,110	$3,180	$13.24	$8.23 - $17.51
Q2 2015	536,634	$8,629	$15.55	$13.71 - $19.20
Q1 2015	159,219	$2,256	$13.01	$9.81 - $15.23
Q4 2014	79,418	$793	$8.56	$8.02 - $10.16
Q2 2014	218,006	$1,927	$8.73	$7.82 - $9.83
Q1 2014	128,484	$1,197	$8.77	$7.32 - $10.25