ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021
Shares 1,366,564 Value ($000) $5,999 Avg Close — Range —
Q1 2021
Shares 1,366,564 Value ($000) $9,921 Avg Close — Range —
Q2 2019
Shares 107,433 Value ($000) $1,503 Avg Close — Range —
Q1 2019
Shares 197,786 Value ($000) $3,536 Avg Close — Range —
Q4 2018
Shares 370,000 Value ($000) $5,820 Avg Close — Range —