ORCHESTRA BIOMED HLDGS INC

Ticker: OBIO CUSIP: 68572M106 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 86,552 Value ($000) $359 Avg Close $4.03 Range $2.42 - $5.42

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	86,552	$359	$4.03	$2.42 - $5.42