ORCHESTRA BIOMED HLDGS INC

Ticker: OBIO CUSIP: 68572M106 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
RTW INVESTMENTS, LP8,306,063$34,470
PERCEPTIVE ADVISORS LLC5,127,256$21,278
VANGUARD GROUP INC1,604,556$6,659
Alyeska Investment Group, L.P.1,000,000$4,150
BlackRock, Inc.630,901$2,618
Affinity Asset Advisors, LLC572,804$2,377
GEODE CAPITAL MANAGEMENT, LLC473,363$1,965
PRICE T ROWE ASSOCIATES INC /MD/364,645$2
CHARLES SCHWAB INVESTMENT MANAGEMENT INC263,788$1,095
Knott David M Jr250,000$1,038
MILLENNIUM MANAGEMENT LLC243,473$1,010
683 Capital Management, LLC204,076$847
JANE STREET GROUP, LLC173,765$721
MARSHALL WACE, LLP171,681$712
Point72 Asset Management, L.P.161,946$672
STATE STREET CORP159,033$660
SUSQUEHANNA INTERNATIONAL GROUP, LLP155,130$644
RENAISSANCE TECHNOLOGIES LLC151,300$628
GOLDMAN SACHS GROUP INC134,073$556
DAFNA Capital Management LLC126,841$526
NORTHERN TRUST CORP110,899$460
Qube Research & Technologies Ltd106,742$443
ExodusPoint Capital Management, LP95,635$397
BARCLAYS PLC94,517$392
IFP Advisors, Inc86,698$360
TWO SIGMA INVESTMENTS, LP86,552$359
MORGAN STANLEY81,851$340
OMERS ADMINISTRATION Corp67,100$278
Holos Integrated Wealth LLC51,595$222
XTX Topco Ltd50,358$209
Hudson Bay Capital Management LP49,425$205
TD Asset Management Inc45,692$190
Squarepoint Ops LLC44,343$184
NewEdge Advisors, LLC44,083$183
MANUFACTURERS LIFE INSURANCE COMPANY, THE32,518$135
CITADEL ADVISORS LLC30,175$125
Meramec Financial Planners, LLC30,000$117
TWO SIGMA ADVISERS, LP27,100$112
BRIDGEWAY CAPITAL MANAGEMENT, LLC25,000$104
Lighthouse Investment Partners, LLC24,900$103
Daytona Street Capital LLC21,500$89
Cresset Asset Management, LLC20,000$83
CITIGROUP INC19,458$81
HighTower Advisors, LLC18,275$76
BALYASNY ASSET MANAGEMENT L.P.18,268$76
BANK OF AMERICA CORP /DE/17,547$73
BNP PARIBAS ARBITRAGE, SA17,007$71
AQR CAPITAL MANAGEMENT LLC16,290$68
Creative Planning16,290$68
Virtu Financial LLC13,623$0
ABLE Financial Group, LLC13,402$56
UBS Group AG11,389$47
GSA CAPITAL PARTNERS LLP10,773$0
China Universal Asset Management Co., Ltd.9,201$38
CANADA PENSION PLAN INVESTMENT BOARD7,100$29
JPMORGAN CHASE & CO4,586$19
Mirae Asset Global Investments Co., Ltd.2,744$11
HARBOUR INVESTMENTS, INC.1,988$8
GF FUND MANAGEMENT CO. LTD.1,109$5
Tower Research Capital LLC (TRC)646$3
ROYAL BANK OF CANADA371$1
Optiver Holding B.V.312$1
SBI Securities Co., Ltd.6$0
Total (63 institutions)21,701,762$88,451