ORCHESTRA BIOMED HLDGS INC

Ticker: OBIO CUSIP: 68572M106 Class: Common Stock

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 171,681 Value ($000) $712 Avg Close $4.03 Range $2.42 - $5.42

Q2 2025

Shares 49,465 Value ($000) $133 Avg Close $2.92 Range $2.37 - $4.06

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	171,681	$712	$4.03	$2.42 - $5.42
Q2 2025	49,465	$133	$2.92	$2.37 - $4.06