ORCHESTRA BIOMED HLDGS INC

Ticker: OBIO CUSIP: 68572M106 Class: Common Stock

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 173,765 Value ($000) $721 Avg Close $4.03 Range $2.42 - $5.42

Q3 2025

Shares 65,524 Value ($000) $162 Avg Close $2.76 Range $2.20 - $3.53

Q2 2025

Shares 18,513 Value ($000) $50 Avg Close $2.92 Range $2.37 - $4.06

Q3 2024

Shares 19,070 Value ($000) $98 Avg Close $6.53 Range $4.48 - $8.87

Q2 2024

Shares 23,782 Value ($000) $194 Avg Close $5.79 Range $4.22 - $8.35

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	173,765	$721	$4.03	$2.42 - $5.42
Q3 2025	65,524	$162	$2.76	$2.20 - $3.53
Q2 2025	18,513	$50	$2.92	$2.37 - $4.06
Q3 2024	19,070	$98	$6.53	$4.48 - $8.87
Q2 2024	23,782	$194	$5.79	$4.22 - $8.35