OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

ROYAL BANK OF CANADA's Holding History (CIK: 0001000275)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 7,200 Value ($000) $3 Avg Close — Range —
Q1 2016
Shares 8,300 Value ($000) $5 Avg Close — Range —
Q4 2015
Shares 11,885 Value ($000) $20 Avg Close — Range —
Q3 2015
Shares 22,942 Value ($000) $48 Avg Close — Range —
Q2 2015
Shares 21,520 Value ($000) $107 Avg Close — Range —
Q1 2015
Shares 15,500 Value ($000) $121 Avg Close — Range —
Q4 2014
Shares 174,772 Value ($000) $1,059 Avg Close — Range —
Q3 2014
Shares 170,543 Value ($000) $726 Avg Close — Range —
Q2 2014
Shares 154,878 Value ($000) $957 Avg Close — Range —
Q1 2014
Shares 138,416 Value ($000) $900 Avg Close — Range —
Q4 2013
Shares 124,816 Value ($000) $703 Avg Close — Range —
Q3 2013
Shares 140,575 Value ($000) $862 Avg Close — Range —
Q2 2013
Shares 16,500 Value ($000) $97 Avg Close — Range —