OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

RENAISSANCE TECHNOLOGIES LLC's Holding History (CIK: 0001037389)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 549,500 Value ($000) $236 Avg Close — Range —
Q1 2016
Shares 2,381,100 Value ($000) $1,340 Avg Close — Range —
Q4 2015
Shares 1,766,200 Value ($000) $3,038 Avg Close — Range —
Q3 2015
Shares 2,780,376 Value ($000) $5,867 Avg Close — Range —
Q2 2015
Shares 420,400 Value ($000) $2,081 Avg Close — Range —