ORUKA THERAPEUTICS INC

Ticker: ORKA CUSIP: 687604108 Class: 0

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 28,566 Value ($000) $866 Avg Close $27.86 Range $18.19 - $32.64

Q3 2025

Shares 28,566 Value ($000) $549 Avg Close $14.82 Range $10.97 - $20.00

Q2 2025

Shares 32,342 Value ($000) $363 Avg Close $10.42 Range $5.49 - $13.70

Q1 2025

Shares 21,831 Value ($000) $224 Avg Close $12.47 Range $9.44 - $21.32

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	28,566	$866	$27.86	$18.19 - $32.64
Q3 2025	28,566	$549	$14.82	$10.97 - $20.00
Q2 2025	32,342	$363	$10.42	$5.49 - $13.70
Q1 2025	21,831	$224	$12.47	$9.44 - $21.32