| FMR LLC | 7,261,384 | $220,093 |
| VR Adviser, LLC | 4,148,428 | $125,739 |
| Fairmount Funds Management LLC | 3,705,262 | $112,306 |
| BlackRock, Inc. | 3,539,415 | $107,280 |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | $80,827 |
| VANGUARD GROUP INC | 2,453,530 | $74,366 |
| Deep Track Capital, LP | 2,161,510 | $65,515 |
| RTW INVESTMENTS, LP | 2,058,148 | $62,382 |
| Commodore Capital LP | 1,753,054 | $53,135 |
| Paradigm Biocapital Advisors LP | 1,710,316 | $51,840 |
| Remedium Capital Partners, LLC | 1,552,414 | $47 |
| PERCEPTIVE ADVISORS LLC | 1,476,501 | $44,753 |
| STATE STREET CORP | 1,383,847 | $41,944 |
| Avoro Capital Advisors LLC | 1,333,340 | $40,414 |
| Blackstone Inc. | 1,165,408 | $35,324 |
| Polar Capital Holdings Plc | 978,288 | $29,652 |
| GEODE CAPITAL MANAGEMENT, LLC | 942,507 | $28,574 |
| FRANKLIN RESOURCES INC | 938,421 | $28,444 |
| Affinity Asset Advisors, LLC | 802,342 | $24,319 |
| MERCER GLOBAL ADVISORS INC /ADV | 745,277 | $22,589 |
| CITADEL ADVISORS LLC | 726,118 | $22,009 |
| Avidity Partners Management LP | 660,424 | $20,017 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 649,346 | $20 |
| Point72 Asset Management, L.P. | 600,000 | $18,186 |
| Woodline Partners LP | 574,553 | $17,415 |
| Cormorant Asset Management, LP | 533,340 | $16,166 |
| Synergy Asset Management, LLC | 458,946 | $13,911 |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | $13,043 |
| Candriam S.C.A. | 400,509 | $12,140 |
| Cable Car Capital, LP | 400,000 | $12,124 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,496 | $9,987 |
| NORTHERN TRUST CORP | 280,904 | $8,514 |
| UBS Group AG | 271,013 | $8,214 |
| Soleus Capital Management, L.P. | 190,000 | $5,759 |
| GREAT POINT PARTNERS LLC | 183,330 | $5,557 |
| BARCLAYS PLC | 173,329 | $5,254 |
| Invesco Ltd. | 143,121 | $4,338 |
| BANK OF AMERICA CORP /DE/ | 139,272 | $4,221 |
| Longaeva Partners L.P. | 128,110 | $3,883 |
| Moody Aldrich Partners LLC | 126,812 | $3,844 |
| MORGAN STANLEY | 122,198 | $3,704 |
| DEUTSCHE BANK AG\ | 119,329 | $3,617 |
| Kalehua Capital Management LLC | 118,524 | $3,592 |
| Sio Capital Management, LLC | 118,126 | $3,580 |
| Bank of New York Mellon Corp | 114,173 | $3,461 |
| Alyeska Investment Group, L.P. | 100,000 | $3,031 |
| GOLDMAN SACHS GROUP INC | 92,995 | $2,819 |
| Nuveen, LLC | 86,347 | $2,617 |
| BRAIDWELL LP | 84,795 | $2,570 |
| WELLINGTON MANAGEMENT GROUP LLP | 84,716 | $2,568 |
| Secure Asset Management, LLC | 81,664 | $2,475 |
| TD Asset Management Inc | 79,896 | $2,422 |
| D. E. Shaw & Co., Inc. | 76,415 | $2,316 |
| abrdn plc | 75,680 | $2,294 |
| B Group, Inc. | 75,000 | $2,273 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,358 | $1,801 |
| Palo Alto Investors LP | 59,985 | $1,818 |
| MILLENNIUM MANAGEMENT LLC | 58,723 | $1,780 |
| AMERICAN CENTURY COMPANIES INC | 57,080 | $1,730 |
| KENNEDY CAPITAL MANAGEMENT LLC | 48,686 | $1,476 |
| WELLS FARGO & COMPANY/MN | 43,261 | $1,311 |
| Swiss National Bank | 43,000 | $1,303 |
| Voya Investment Management LLC | 42,503 | $1,288 |
| RHUMBLINE ADVISERS | 41,017 | $1,243 |
| ALPS ADVISORS INC | 39,751 | $1,205 |
| Rafferty Asset Management, LLC | 38,485 | $1,166 |
| ALLIANCEBERNSTEIN L.P. | 37,800 | $1,146 |
| Verition Fund Management LLC | 35,710 | $1,082 |
| Financial Enhancement Group LLC | 31,293 | $1,078 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,184 | $850 |
| TWO SIGMA INVESTMENTS, LP | 28,566 | $866 |
| Squarepoint Ops LLC | 27,671 | $839 |
| Voleon Capital Management LP | 23,548 | $714 |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,968 | $696 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,658 | $656 |
| MetLife Investment Management, LLC | 21,362 | $647 |
| ADAR1 Capital Management, LLC | 20,840 | $632 |
| JPMORGAN CHASE & CO | 20,417 | $619 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,152 | $608 |
| Hudson Bay Capital Management LP | 20,000 | $606 |
| GLENMEDE TRUST CO NA | 19,485 | $591 |
| Legal & General Group Plc | 18,744 | $568 |
| Brookwood Investment Group LLC | 16,569 | $502 |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 15,406 | $467 |
| ENVESTNET ASSET MANAGEMENT INC | 15,247 | $462 |
| AlphaQuest LLC | 14,901 | $452 |
| INTECH INVESTMENT MANAGEMENT LLC | 14,813 | $449 |
| PROFUND ADVISORS LLC | 14,623 | $443 |
| UBS ASSET MANAGEMENT AMERICAS INC | 14,244 | $432 |
| Resolute Capital Asset Partners LLC | 12,500 | $379 |
| JANUS HENDERSON GROUP PLC | 12,100 | $367 |
| AlphaCentric Advisors LLC | 10,880 | $330 |
| ALTFEST L J & CO INC | 10,857 | $329 |
| Allianz Asset Management GmbH | 10,300 | $312 |
| Police & Firemen's Retirement System of New Jersey | 10,207 | $309 |
| CITIGROUP INC | 9,828 | $298 |
| SEI INVESTMENTS CO | 9,676 | $293 |
| Brevan Howard Capital Management LP | 9,416 | $285 |
| ProShare Advisors LLC | 9,189 | $279 |
| Virtus Investment Advisers, LLC | 8,814 | $267 |
| 42 other institutions | 94,026 | $2,538 |