OTONOMY INC

CUSIP: 68906L105 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 113,000 Value ($000) $2,598 Avg Close — Range —
Q1 2015
Shares 70,000 Value ($000) $2,475 Avg Close — Range —
Q3 2014
Shares 111,085 Value ($000) $2,666 Avg Close — Range —