PTC THERAPEUTICS INC

Ticker: PTCT CUSIP: 69366J200 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 24,310 Value ($000) $1,847 Avg Close $72.67 Range $60.80 - $87.50

Q3 2025

Shares 24,341 Value ($000) $1,494 Avg Close $52.09 Range $43.17 - $63.19

Q2 2025

Shares 50,851 Value ($000) $2,484 Avg Close $47.47 Range $35.95 - $52.98

Q1 2025

Shares 80,100 Value ($000) $4,082 Avg Close $49.90 Range $41.66 - $58.38

Q4 2024

Shares 173,352 Value ($000) $7,825 Avg Close $42.80 Range $34.57 - $54.16

Q3 2024

Shares 317,297 Value ($000) $11,772 Avg Close $33.48 Range $29.02 - $38.62

Q2 2024

Shares 318,173 Value ($000) $9,730 Avg Close $32.39 Range $24.00 - $40.69

Q1 2024

Shares 196,651 Value ($000) $5,721 Avg Close $28.01 Range $23.58 - $32.91

Q3 2023

Shares 132,331 Value ($000) $2,966 Avg Close $37.19 Range $22.03 - $42.63

Q2 2023

Shares 43,272 Value ($000) $1,760 Avg Close $48.93 Range $39.66 - $59.84

Q1 2023

Shares 134,141 Value ($000) $6,498 Avg Close $45.71 Range $37.25 - $50.20

Q4 2022

Shares 241,212 Value ($000) $9,207 Avg Close $41.57 Range $33.25 - $55.25

Q3 2022

Shares 307,156 Value ($000) $15,419 Avg Close $49.00 Range $40.00 - $55.58

Q2 2021

Shares 74,489 Value ($000) $3,149 Avg Close $42.85 Range $37.12 - $50.26

Q1 2021

Shares 93,978 Value ($000) $4,450 Avg Close $59.38 Range $46.51 - $70.82

Q4 2020

Shares 26,541 Value ($000) $1,620 Avg Close $58.94 Range $46.86 - $68.81

Q1 2020

Shares 182,611 Value ($000) $8,146 Avg Close $50.35 Range $30.79 - $59.89

Q4 2019

Shares 275,147 Value ($000) $13,215 Avg Close $42.49 Range $31.49 - $50.96

Q3 2018

Shares 45,147 Value ($000) $2,122 Avg Close $41.38 Range $32.13 - $48.85

Q1 2018

Shares 657,654 Value ($000) $17,796 Avg Close $25.34 Range $16.38 - $33.22

Q4 2017

Shares 251,698 Value ($000) $4,198 Avg Close $16.93 Range $14.87 - $21.58

Q2 2015

Shares 36,545 Value ($000) $1,759 Avg Close $58.34 Range $46.17 - $78.72

Q1 2015

Shares 177,749 Value ($000) $10,816 Avg Close $61.01 Range $46.91 - $77.87

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	24,310	$1,847	$72.67	$60.80 - $87.50
Q3 2025	24,341	$1,494	$52.09	$43.17 - $63.19
Q2 2025	50,851	$2,484	$47.47	$35.95 - $52.98
Q1 2025	80,100	$4,082	$49.90	$41.66 - $58.38
Q4 2024	173,352	$7,825	$42.80	$34.57 - $54.16
Q3 2024	317,297	$11,772	$33.48	$29.02 - $38.62
Q2 2024	318,173	$9,730	$32.39	$24.00 - $40.69
Q1 2024	196,651	$5,721	$28.01	$23.58 - $32.91
Q3 2023	132,331	$2,966	$37.19	$22.03 - $42.63
Q2 2023	43,272	$1,760	$48.93	$39.66 - $59.84
Q1 2023	134,141	$6,498	$45.71	$37.25 - $50.20
Q4 2022	241,212	$9,207	$41.57	$33.25 - $55.25
Q3 2022	307,156	$15,419	$49.00	$40.00 - $55.58
Q2 2021	74,489	$3,149	$42.85	$37.12 - $50.26
Q1 2021	93,978	$4,450	$59.38	$46.51 - $70.82
Q4 2020	26,541	$1,620	$58.94	$46.86 - $68.81
Q1 2020	182,611	$8,146	$50.35	$30.79 - $59.89
Q4 2019	275,147	$13,215	$42.49	$31.49 - $50.96
Q3 2018	45,147	$2,122	$41.38	$32.13 - $48.85
Q1 2018	657,654	$17,796	$25.34	$16.38 - $33.22
Q4 2017	251,698	$4,198	$16.93	$14.87 - $21.58
Q2 2015	36,545	$1,759	$58.34	$46.17 - $78.72
Q1 2015	177,749	$10,816	$61.01	$46.91 - $77.87