| BlackRock, Inc. | 12,779,065 | $970,698 |
| VANGUARD GROUP INC | 8,803,203 | $668,691 |
| RTW INVESTMENTS, LP | 7,746,415 | $588,418 |
| JANUS HENDERSON GROUP PLC | 4,851,332 | $368,587 |
| STATE STREET CORP | 4,206,126 | $319,497 |
| TORONTO DOMINION BANK | 4,138,215 | $314,339 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,867,380 | $293,766 |
| ARMISTICE CAPITAL, LLC | 2,801,869 | $212,830 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,016,062 | $153,164 |
| D. E. Shaw & Co., Inc. | 1,744,991 | $132,550 |
| FMR LLC | 1,681,216 | $127,705 |
| Jefferies Financial Group Inc. | 1,658,481 | $125,978 |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | $113,940 |
| BANK OF AMERICA CORP /DE/ | 1,431,557 | $108,741 |
| FRANKLIN RESOURCES INC | 1,286,685 | $97,737 |
| CITADEL ADVISORS LLC | 1,154,455 | $87,692 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,136,188 | $86,305 |
| Point72 Asset Management, L.P. | 1,128,551 | $85,725 |
| GOLDMAN SACHS GROUP INC | 1,023,091 | $77,714 |
| Hood River Capital Management LLC | 1,003,075 | $76,194 |
| Pictet Asset Management Holding SA | 978,957 | $74,789 |
| UBS Group AG | 964,658 | $73,275 |
| MORGAN STANLEY | 905,192 | $68,758 |
| Palo Alto Investors LP | 903,916 | $68,661 |
| SG Americas Securities, LLC | 894,461 | $68 |
| BNP PARIBAS ARBITRAGE, SA | 828,662 | $62,945 |
| NORTHERN TRUST CORP | 769,420 | $58,445 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 734,933 | $55,826 |
| Nuveen, LLC | 699,190 | $53,110 |
| Avoro Capital Advisors LLC | 685,000 | $52,033 |
| BNP Paribas Investment Partners S.A. | 647,585 | $49 |
| LORD, ABBETT & CO. LLC | 627,106 | $48 |
| DIMENSIONAL FUND ADVISORS LP | 627,092 | $47,634 |
| RENAISSANCE TECHNOLOGIES LLC | 607,589 | $46,152 |
| Woodline Partners LP | 571,553 | $43,415 |
| Bank of New York Mellon Corp | 514,680 | $39,095 |
| Boston Partners | 487,977 | $37,066 |
| PRINCIPAL FINANCIAL GROUP INC | 478,897 | $36,377 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 460,114 | $35 |
| Invesco Ltd. | 434,285 | $32,988 |
| MPM BioImpact LLC | 430,013 | $32,664 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 426,506 | $32,397 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 406,410 | $30,871 |
| Rockefeller Capital Management L.P. | 405,536 | $30,805 |
| Legal & General Group Plc | 366,265 | $27,821 |
| JUPITER ASSET MANAGEMENT LTD | 361,159 | $27,434 |
| PANAGORA ASSET MANAGEMENT INC | 359,837 | $27,333 |
| JPMORGAN CHASE & CO | 356,041 | $27,045 |
| AQR CAPITAL MANAGEMENT LLC | 341,927 | $25,973 |
| Voya Investment Management LLC | 339,146 | $25,762 |
| Public Sector Pension Investment Board | 324,636 | $24,659 |
| Ensign Peak Advisors, Inc | 280,572 | $21,312 |
| Russell Investments Group, Ltd. | 270,748 | $20,566 |
| Empowered Funds, LLC | 250,412 | $19,021 |
| MARSHALL WACE, LLP | 247,746 | $18,819 |
| MACKENZIE FINANCIAL CORP | 236,909 | $18,015 |
| Pacer Advisors, Inc. | 235,653 | $17,900 |
| DEUTSCHE BANK AG\ | 231,268 | $17,567 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 220,847 | $16,776 |
| BARCLAYS PLC | 220,196 | $16,726 |
| RHUMBLINE ADVISERS | 207,950 | $15,796 |
| Boxer Capital Management, LLC | 200,000 | $15,192 |
| PRUDENTIAL FINANCIAL INC | 183,185 | $13,915 |
| Parkman Healthcare Partners LLC | 160,179 | $12,167 |
| BI Asset Management Fondsmaeglerselskab A/S | 159,477 | $12 |
| FIRST TRUST ADVISORS LP | 155,596 | $11,819 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 151,401 | $11,502 |
| AMERIPRISE FINANCIAL INC | 147,584 | $11,210 |
| Swiss National Bank | 141,065 | $10,715 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 141,000 | $10,710 |
| UBS ASSET MANAGEMENT AMERICAS INC | 131,893 | $10,019 |
| Ikarian Capital, LLC | 118,657 | $9,013 |
| FEDERATED HERMES, INC. | 112,566 | $8,551 |
| NEUBERGER BERMAN GROUP LLC | 111,590 | $8,476 |
| WCM INVESTMENT MANAGEMENT, LLC | 110,267 | $8,401 |
| CASTLEARK MANAGEMENT LLC | 96,860 | $7,357 |
| ALLIANCEBERNSTEIN L.P. | 94,308 | $7,164 |
| SEI INVESTMENTS CO | 92,089 | $6,995 |
| WELLS FARGO & COMPANY/MN | 86,921 | $6,603 |
| RAYMOND JAMES FINANCIAL INC | 85,998 | $6,532 |
| PINNACLE ASSOCIATES LTD | 83,431 | $6,337 |
| ROYCE & ASSOCIATES LP | 80,794 | $6,137 |
| Rafferty Asset Management, LLC | 78,507 | $5,963 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 78,150 | $6 |
| FCF Advisors LLC | 75,757 | $5,755 |
| Hillsdale Investment Management Inc. | 75,706 | $5,751 |
| CANADA PENSION PLAN INVESTMENT BOARD | 75,400 | $5,727 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 72,597 | $5,531 |
| Alyeska Investment Group, L.P. | 72,307 | $5,492 |
| EAM Investors, LLC | 71,735 | $5,449 |
| ACADIAN ASSET MANAGEMENT LLC | 69,504 | $5 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,293 | $5,188 |
| HRT FINANCIAL LP | 67,064 | $5 |
| SECTOR GAMMA AS | 61,923 | $4,704 |
| Rock Springs Capital Management LP | 61,879 | $4,700 |
| VICTORY CAPITAL MANAGEMENT INC | 56,571 | $4,297 |
| Thrivent Financial for Lutherans | 55,169 | $4 |
| Assenagon Asset Management S.A. | 54,170 | $4,115 |
| NORGES BANK | 53,807 | $4,087 |
| SEGALL BRYANT & HAMILL, LLC | 50,431 | $3,831 |
| 247 other institutions | 2,553,936 | $167,428 |