| PERCEPTIVE ADVISORS LLC | 12,050,000 | $28,318 |
| Commodore Capital LP | 11,445,000 | $26,896 |
| JANUS HENDERSON GROUP PLC | 10,540,334 | $24,822 |
| Point72 Asset Management, L.P. | 10,495,252 | $24,664 |
| Octagon Capital Advisors LP | 9,567,898 | $22,485 |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | $16,742 |
| AMERIPRISE FINANCIAL INC | 6,911,237 | $16,241 |
| Eversept Partners, LP | 5,391,548 | $12,670 |
| FRANKLIN RESOURCES INC | 5,092,562 | $11,968 |
| Boxer Capital Management, LLC | 4,799,875 | $11,280 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | $10,575 |
| B Group, Inc. | 4,500,000 | $10,575 |
| Squadron Capital Management LLC | 4,500,000 | $10,575 |
| STEMPOINT CAPITAL LP | 4,192,375 | $9,852 |
| MORGAN STANLEY | 4,142,446 | $9,735 |
| RENAISSANCE TECHNOLOGIES LLC | 2,382,500 | $5,599 |
| Vivo Capital, LLC | 2,293,578 | $5,390 |
| VANGUARD GROUP INC | 2,115,622 | $4,972 |
| ADAR1 Capital Management, LLC | 2,004,845 | $4,711 |
| Artia Global Partners LP | 1,992,367 | $4,682 |
| BlackRock, Inc. | 1,879,319 | $4,416 |
| ORBIMED ADVISORS LLC | 1,871,420 | $4,398 |
| CITADEL ADVISORS LLC | 1,701,411 | $3,998 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,577,856 | $4 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,565,452 | $3,681 |
| HighVista Strategies LLC | 1,300,031 | $3,055 |
| Exome Asset Management LLC | 758,203 | $1,782 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 664,087 | $1,561 |
| Hudson Bay Capital Management LP | 656,460 | $1,543 |
| STATE STREET CORP | 643,997 | $1,513 |
| GOLDMAN SACHS GROUP INC | 557,565 | $1,310 |
| Persistent Asset Partners Ltd | 416,035 | $978 |
| Resolute Capital Asset Partners LLC | 400,000 | $940 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 367,103 | $863 |
| JANE STREET GROUP, LLC | 343,686 | $808 |
| Seven Fleet Capital Management LP | 327,500 | $770 |
| BALYASNY ASSET MANAGEMENT L.P. | 325,367 | $765 |
| Squarepoint Ops LLC | 322,090 | $757 |
| Creek Drive Management Group LLC | 307,500 | $723 |
| BIT Capital GmbH | 305,000 | $717 |
| MILLENNIUM MANAGEMENT LLC | 294,486 | $692 |
| NORTHERN TRUST CORP | 283,147 | $665 |
| Ikarian Capital, LLC | 274,978 | $646 |
| UBS Group AG | 247,754 | $582 |
| Quadrature Capital Ltd | 240,586 | $565 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 212,659 | $500 |
| Scientech Research LLC | 211,441 | $497 |
| TD Asset Management Inc | 204,448 | $480 |
| SPHERA FUNDS MANAGEMENT LTD. | 184,100 | $433 |
| DIADEMA PARTNERS LP | 166,049 | $390 |
| ACT CAPITAL MANAGEMENT, LLC | 150,000 | $353 |
| BOOTHBAY FUND MANAGEMENT, LLC | 132,648 | $312 |
| OMERS ADMINISTRATION Corp | 108,000 | $254 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 106,636 | $252 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 102,108 | $240 |
| Pale Fire Capital SE | 70,710 | $166 |
| BANK OF AMERICA CORP /DE/ | 70,097 | $165 |
| CITIGROUP INC | 52,281 | $123 |
| Jefferies Financial Group Inc. | 46,761 | $110 |
| Virtus ETF Advisers LLC | 46,000 | $108 |
| Lighthouse Investment Partners, LLC | 39,480 | $93 |
| Caitong International Asset Management Co., Ltd | 34,504 | $81 |
| Total Clarity Wealth Management, Inc. | 29,935 | $70 |
| TWO SIGMA INVESTMENTS, LP | 27,640 | $65 |
| XTX Topco Ltd | 21,669 | $51 |
| Vontobel Holding Ltd. | 20,000 | $47 |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,650 | $39 |
| VICTORY CAPITAL MANAGEMENT INC | 16,072 | $38 |
| LPL Financial LLC | 15,154 | $36 |
| Newbridge Financial Services Group, Inc. | 15,000 | $35 |
| WINTON GROUP Ltd | 14,891 | $35 |
| BARCLAYS PLC | 14,780 | $35 |
| Atom Investors LP | 14,041 | $33 |
| Bank of New York Mellon Corp | 12,912 | $30 |
| Virtu Financial LLC | 11,870 | $0 |
| Schonfeld Strategic Advisors LLC | 11,231 | $26 |
| Cetera Investment Advisers | 10,512 | $25 |
| FNY Investment Advisers, LLC | 9,951 | $0 |
| Tower Research Capital LLC (TRC) | 1,025 | $2 |
| Avion Wealth | 500 | $0 |
| Rockefeller Capital Management L.P. | 500 | $1 |
| Federation des caisses Desjardins du Quebec | 100 | $0 |
| OSAIC HOLDINGS, INC. | 66 | $0 |
| SHP Wealth Management | 50 | $0 |
| WELLS FARGO & COMPANY/MN | 21 | $0 |
| FMR LLC | 10 | $0 |