PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

US BANCORP \DE\'s Holding History (CIK: 0000036104)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,825 Value ($000) $538 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 112 Value ($000) $6 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 166 Value ($000) $7 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 866 Value ($000) $33 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 968 Value ($000) $74 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 2,289 Value ($000) $132 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 1,684 Value ($000) $70 Avg Close $47.26 Range $33.01 - $63.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,825	$538	$186.22	$50.31 - $317.72
Q3 2025	112	$6	$48.49	$37.19 - $61.03
Q2 2025	166	$7	$38.08	$26.70 - $46.93
Q1 2025	866	$33	$62.45	$30.01 - $91.83
Q4 2024	968	$74	$72.36	$55.33 - $86.93
Q3 2024	2,289	$132	$54.02	$38.99 - $63.93
Q2 2024	1,684	$70	$47.26	$33.01 - $63.00