| JANUS HENDERSON GROUP PLC | 3,240,086 | $954,834 |
| BlackRock, Inc. | 2,078,500 | $612,617 |
| PERCEPTIVE ADVISORS LLC | 1,995,986 | $588,297 |
| VANGUARD GROUP INC | 1,460,933 | $430,595 |
| FMR LLC | 1,358,675 | $400,456 |
| Orbis Allan Gray Ltd | 1,255,162 | $369,946 |
| BAKER BROS. ADVISORS LP | 1,126,488 | $332,021 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 965,313 | $284,516 |
| Cormorant Asset Management, LP | 950,000 | $280,003 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,061 | $275,010 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 903,351 | $266,254 |
| MORGAN STANLEY | 889,889 | $262,286 |
| STATE STREET CORP | 882,215 | $260,024 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 785,987 | $232 |
| GOLDMAN SACHS GROUP INC | 716,184 | $211,088 |
| GEODE CAPITAL MANAGEMENT, LLC | 562,379 | $165,783 |
| BARCLAYS PLC | 530,751 | $156,434 |
| BANK OF AMERICA CORP /DE/ | 522,763 | $154,079 |
| Point72 Asset Management, L.P. | 492,346 | $145,114 |
| Assenagon Asset Management S.A. | 408,787 | $120,486 |
| Logos Global Management LP | 375,000 | $110,528 |
| RA CAPITAL MANAGEMENT, L.P. | 373,787 | $110,170 |
| Soleus Capital Management, L.P. | 362,966 | $106,981 |
| FRANKLIN RESOURCES INC | 356,074 | $104,949 |
| Vivo Capital, LLC | 328,895 | $96,939 |
| Hood River Capital Management LLC | 289,467 | $85,318 |
| Pictet Asset Management Holding SA | 240,588 | $71,085 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,301 | $58,447 |
| NORTHERN TRUST CORP | 192,284 | $56,674 |
| Affinity Asset Advisors, LLC | 185,000 | $54,527 |
| WELLINGTON MANAGEMENT GROUP LLP | 176,562 | $52,040 |
| Qube Research & Technologies Ltd | 168,897 | $49,781 |
| abrdn plc | 134,992 | $39,788 |
| Sofinnova Investments, Inc. | 125,722 | $37,055 |
| Candriam S.C.A. | 110,590 | $32,597 |
| Woodline Partners LP | 105,412 | $31,069 |
| Velan Capital Investment Management LP | 100,781 | $29,704 |
| ORBIMED ADVISORS LLC | 94,500 | $27,853 |
| UBS Group AG | 89,200 | $26,291 |
| FIRST TRUST ADVISORS LP | 88,704 | $26,145 |
| Ikarian Capital, LLC | 86,581 | $25,519 |
| ACUTA CAPITAL PARTNERS, LLC | 83,036 | $24,474 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 82,465 | $24,306 |
| ALGERT GLOBAL LLC | 80,640 | $24 |
| Bank of New York Mellon Corp | 77,897 | $22,959 |
| Invesco Ltd. | 77,088 | $22,721 |
| AMERICAN CENTURY COMPANIES INC | 75,366 | $22,214 |
| Alyeska Investment Group, L.P. | 74,376 | $21,922 |
| CANADA PENSION PLAN INVESTMENT BOARD | 69,712 | $20,547 |
| MARSHALL WACE, LLP | 69,242 | $20,408 |
| EVENTIDE ASSET MANAGEMENT, LLC | 67,100 | $19,777 |
| RENAISSANCE TECHNOLOGIES LLC | 66,230 | $19,521 |
| 72 Investment Holdings, LLC | 65,933 | $19,433 |
| Ensign Peak Advisors, Inc | 64,283 | $18,947 |
| Exome Asset Management LLC | 58,122 | $17,131 |
| JPMORGAN CHASE & CO | 55,300 | $16,299 |
| DEUTSCHE BANK AG\ | 50,811 | $14,976 |
| Nuveen, LLC | 49,970 | $14,728 |
| Boxer Capital Management, LLC | 46,457 | $13,693 |
| TD Asset Management Inc | 46,146 | $13,601 |
| KVP Capital Advisors, LP | 42,900 | $12,644 |
| Moody Aldrich Partners LLC | 41,731 | $12,300 |
| SummitTX Capital, L.P. | 41,629 | $12,270 |
| Swiss National Bank | 40,500 | $11,937 |
| Integral Health Asset Management, LLC | 40,000 | $11,790 |
| Ishara Investments LP | 40,000 | $11,790 |
| D. E. Shaw & Co., Inc. | 37,481 | $11,047 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,377 | $11,016 |
| Empowered Funds, LLC | 36,852 | $10,862 |
| READYSTATE ASSET MANAGEMENT LP | 36,792 | $10,844 |
| First Turn Management, LLC | 35,749 | $10,537 |
| UBS ASSET MANAGEMENT AMERICAS INC | 35,288 | $10,401 |
| CITADEL ADVISORS LLC | 34,917 | $10,291 |
| Caption Management, LLC | 33,300 | $9,815 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,291 | $9,862 |
| B Group, Inc. | 33,237 | $9,796 |
| CONGRESS ASSET MANAGEMENT CO /MA | 31,246 | $9,209 |
| PFM Health Sciences, LP | 31,163 | $9,185 |
| LORD, ABBETT & CO. LLC | 30,756 | $9 |
| ArrowMark Colorado Holdings LLC | 30,000 | $8,842 |
| AQR CAPITAL MANAGEMENT LLC | 28,828 | $8,497 |
| RHUMBLINE ADVISERS | 28,324 | $8,348 |
| HighVista Strategies LLC | 25,841 | $7,616 |
| NEUBERGER BERMAN GROUP LLC | 25,678 | $7,568 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,559 | $7,536 |
| WELLS FARGO & COMPANY/MN | 25,235 | $7,438 |
| ALLIANCEBERNSTEIN L.P. | 25,070 | $7,389 |
| Burkehill Global Management, LP | 25,000 | $7,369 |
| DIMENSIONAL FUND ADVISORS LP | 23,543 | $6,939 |
| Susquehanna Portfolio Strategies, LLC | 23,251 | $6,853 |
| TWO SIGMA INVESTMENTS, LP | 23,098 | $6,808 |
| Tetragon Partners GP Ltd | 22,952 | $6,765 |
| AMERIPRISE FINANCIAL INC | 22,715 | $6,695 |
| Rafferty Asset Management, LLC | 22,240 | $6,555 |
| Man Group plc | 21,170 | $6,240 |
| STEMPOINT CAPITAL LP | 21,067 | $6,209 |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,974 | $6,182 |
| EAM Investors, LLC | 20,941 | $6,172 |
| Russell Investments Group, Ltd. | 20,612 | $6,075 |
| Ally Bridge Group (NY) LLC | 19,882 | $5,860 |
| 148 other institutions | 511,146 | $140,862 |