PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

STATE STREET CORP's Holding History (CIK: 0000093751)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 882,215 Value ($000) $260,024 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 907,108 Value ($000) $48,077 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 698,093 Value ($000) $29,355 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 737,039 Value ($000) $27,912 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 768,655 Value ($000) $59,156 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 789,624 Value ($000) $45,435 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 819,142 Value ($000) $33,880 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 44,508 Value ($000) $2,716 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 30,708 Value ($000) $684 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	882,215	$260,024	$186.22	$50.31 - $317.72
Q3 2025	907,108	$48,077	$48.49	$37.19 - $61.03
Q2 2025	698,093	$29,355	$38.08	$26.70 - $46.93
Q1 2025	737,039	$27,912	$62.45	$30.01 - $91.83
Q4 2024	768,655	$59,156	$72.36	$55.33 - $86.93
Q3 2024	789,624	$45,435	$54.02	$38.99 - $63.93
Q2 2024	819,142	$33,880	$47.26	$33.01 - $63.00
Q1 2024	44,508	$2,716	$44.86	$20.50 - $67.21
Q4 2023	30,708	$684	$18.01	$13.01 - $27.60