PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,358,675 Value ($000) $400,456 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 43,211 Value ($000) $2,290 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 38,100 Value ($000) $1,602 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 35,719 Value ($000) $1,353 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 188,367 Value ($000) $14,497 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 273,895 Value ($000) $15,760 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 290,979 Value ($000) $12,035 Avg Close $47.26 Range $33.01 - $63.00

Q1 2024

Shares 442,621 Value ($000) $27,009 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 115 Value ($000) $3 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,358,675	$400,456	$186.22	$50.31 - $317.72
Q3 2025	43,211	$2,290	$48.49	$37.19 - $61.03
Q2 2025	38,100	$1,602	$38.08	$26.70 - $46.93
Q1 2025	35,719	$1,353	$62.45	$30.01 - $91.83
Q4 2024	188,367	$14,497	$72.36	$55.33 - $86.93
Q3 2024	273,895	$15,760	$54.02	$38.99 - $63.93
Q2 2024	290,979	$12,035	$47.26	$33.01 - $63.00
Q1 2024	442,621	$27,009	$44.86	$20.50 - $67.21
Q4 2023	115	$3	$18.01	$13.01 - $27.60