PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

TEACHER RETIREMENT SYSTEM OF TEXAS's Holding History (CIK: 0000796848)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,053 Value ($000) $900 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 4,469 Value ($000) $237 Avg Close $48.49 Range $37.19 - $61.03

Q4 2024

Shares 3,961 Value ($000) $0 Avg Close $72.36 Range $55.33 - $86.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,053	$900	$186.22	$50.31 - $317.72
Q3 2025	4,469	$237	$48.49	$37.19 - $61.03
Q4 2024	3,961	$0	$72.36	$55.33 - $86.93