PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

STATE OF WISCONSIN INVESTMENT BOARD's Holding History (CIK: 0000854157)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,231 Value ($000) $4,489 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 9,033 Value ($000) $479 Avg Close $48.49 Range $37.19 - $61.03

Q2 2025

Shares 14,759 Value ($000) $621 Avg Close $38.08 Range $26.70 - $46.93

Q1 2025

Shares 14,611 Value ($000) $553 Avg Close $62.45 Range $30.01 - $91.83

Q4 2024

Shares 10,682 Value ($000) $822 Avg Close $72.36 Range $55.33 - $86.93

Q3 2024

Shares 12,648 Value ($000) $728 Avg Close $54.02 Range $38.99 - $63.93

Q2 2024

Shares 11,950 Value ($000) $494 Avg Close $47.26 Range $33.01 - $63.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,231	$4,489	$186.22	$50.31 - $317.72
Q3 2025	9,033	$479	$48.49	$37.19 - $61.03
Q2 2025	14,759	$621	$38.08	$26.70 - $46.93
Q1 2025	14,611	$553	$62.45	$30.01 - $91.83
Q4 2024	10,682	$822	$72.36	$55.33 - $86.93
Q3 2024	12,648	$728	$54.02	$38.99 - $63.93
Q2 2024	11,950	$494	$47.26	$33.01 - $63.00