PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

ACADIAN ASSET MANAGEMENT LLC's Holding History (CIK: 0000916542)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 629 Value ($000) $0 Avg Close $186.22 Range $50.31 - $317.72

Q3 2024

Shares 1,189 Value ($000) $0 Avg Close $54.02 Range $38.99 - $63.93

Q1 2024

Shares 82,254 Value ($000) $5 Avg Close $44.86 Range $20.50 - $67.21

Q4 2023

Shares 98,049 Value ($000) $2 Avg Close $18.01 Range $13.01 - $27.60

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	629	$0	$186.22	$50.31 - $317.72
Q3 2024	1,189	$0	$54.02	$38.99 - $63.93
Q1 2024	82,254	$5	$44.86	$20.50 - $67.21
Q4 2023	98,049	$2	$18.01	$13.01 - $27.60