PRAXIS PRECISION MEDICINES I

Ticker: PRAX CUSIP: 74006W207 Class: Common Stock

VIRGINIA RETIREMENT SYSTEMS ET AL's Holding History (CIK: 0001005354)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,500 Value ($000) $1,032 Avg Close $186.22 Range $50.31 - $317.72

Q3 2025

Shares 3,900 Value ($000) $207 Avg Close $48.49 Range $37.19 - $61.03

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,500	$1,032	$186.22	$50.31 - $317.72
Q3 2025	3,900	$207	$48.49	$37.19 - $61.03